Application of whole-genome sequencing to an unusual outbreak of invasive group a streptococcal disease

Jessica Galloway-Peña; Meredith E. Clement; Batu K.Sharma Kuinkel; Felicia Ruffin; Anthony R. Flores; Howard Levinson; Samuel A. Shelburne; Zack Moore; Vance G. Fowler

doi:10.1093/ofid/ofw042

Application of whole-genome sequencing to an unusual outbreak of invasive group a streptococcal disease

Jessica Galloway-Peña, Meredith E. Clement, Batu K.Sharma Kuinkel, Felicia Ruffin, Anthony R. Flores, Howard Levinson, Samuel A. Shelburne, Zack Moore, Vance G. Fowler

Research output: Contribution to journal › Article

7 Scopus citations

Abstract

Whole-genome analysis was applied to investigate atypical point-source transmission of 2 invasive group A streptococcal (GAS) infections. Isolates were serotype M4, ST39, and genetically indistinguishable. Comparison with MGAS10750 revealed nonsynonymous polymorphisms in ropB and increased speB transcription. This study demonstrates the usefulness of whole-genome analyses for GAS outbreaks.

Original language	English (US)
Journal	Open Forum Infectious Diseases
Volume	3
Issue number	1
DOIs	https://doi.org/10.1093/ofid/ofw042
State	Published - Jan 1 2016

Keywords

Group A streptococcus
Invasive disease
Streptococcus pyogenes
Whole-genome sequencing
speB

ASJC Scopus subject areas

Oncology
Clinical Neurology

Access to Document

10.1093/ofid/ofw042

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Application of whole-genome sequencing to an unusual outbreak of invasive group a streptococcal disease. / Galloway-Peña, Jessica; Clement, Meredith E.; Kuinkel, Batu K.Sharma; Ruffin, Felicia; Flores, Anthony R.; Levinson, Howard; Shelburne, Samuel A.; Moore, Zack; Fowler, Vance G.

In: Open Forum Infectious Diseases, Vol. 3, No. 1, 01.01.2016.

Research output: Contribution to journal › Article

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