Application of whole-genome sequencing to an unusual outbreak of invasive group a streptococcal disease

Jessica Galloway-Peña, Meredith E. Clement, Batu K.Sharma Kuinkel, Felicia Ruffin, Anthony R. Flores, Howard Levinson, Samuel A. Shelburne, Zack Moore, Vance G. Fowler

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

Whole-genome analysis was applied to investigate atypical point-source transmission of 2 invasive group A streptococcal (GAS) infections. Isolates were serotype M4, ST39, and genetically indistinguishable. Comparison with MGAS10750 revealed nonsynonymous polymorphisms in ropB and increased speB transcription. This study demonstrates the usefulness of whole-genome analyses for GAS outbreaks.

Original languageEnglish (US)
JournalOpen Forum Infectious Diseases
Volume3
Issue number1
DOIs
StatePublished - Jan 1 2016

Keywords

  • Group A streptococcus
  • Invasive disease
  • Streptococcus pyogenes
  • Whole-genome sequencing
  • speB

ASJC Scopus subject areas

  • Oncology
  • Clinical Neurology

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