TY - JOUR
T1 - Application of whole-genome sequencing to an unusual outbreak of invasive group a streptococcal disease
AU - Galloway-Peña, Jessica
AU - Clement, Meredith E.
AU - Kuinkel, Batu K.Sharma
AU - Ruffin, Felicia
AU - Flores, Anthony R.
AU - Levinson, Howard
AU - Shelburne, Samuel A.
AU - Moore, Zack
AU - Fowler, Vance G.
PY - 2016/1/1
Y1 - 2016/1/1
N2 - Whole-genome analysis was applied to investigate atypical point-source transmission of 2 invasive group A streptococcal (GAS) infections. Isolates were serotype M4, ST39, and genetically indistinguishable. Comparison with MGAS10750 revealed nonsynonymous polymorphisms in ropB and increased speB transcription. This study demonstrates the usefulness of whole-genome analyses for GAS outbreaks.
AB - Whole-genome analysis was applied to investigate atypical point-source transmission of 2 invasive group A streptococcal (GAS) infections. Isolates were serotype M4, ST39, and genetically indistinguishable. Comparison with MGAS10750 revealed nonsynonymous polymorphisms in ropB and increased speB transcription. This study demonstrates the usefulness of whole-genome analyses for GAS outbreaks.
KW - Group A streptococcus
KW - Invasive disease
KW - Streptococcus pyogenes
KW - Whole-genome sequencing
KW - speB
UR - http://www.scopus.com/inward/record.url?scp=85000580156&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85000580156&partnerID=8YFLogxK
U2 - 10.1093/ofid/ofw042
DO - 10.1093/ofid/ofw042
M3 - Article
AN - SCOPUS:85000580156
VL - 3
JO - Open Forum Infectious Diseases
JF - Open Forum Infectious Diseases
SN - 2328-8957
IS - 1
ER -