Application of whole-genome sequencing to an unusual outbreak of invasive group a streptococcal disease

Jessica Galloway-Peña; Meredith E. Clement; Batu K.Sharma Kuinkel; Felicia Ruffin; Anthony R. Flores; Howard Levinson; Samuel A. Shelburne; Zack Moore; Vance G. Fowler

doi:10.1093/ofid/ofw042

Application of whole-genome sequencing to an unusual outbreak of invasive group a streptococcal disease

Jessica Galloway-Peña, Meredith E. Clement, Batu K.Sharma Kuinkel, Felicia Ruffin, Anthony R. Flores, Howard Levinson, Samuel A. Shelburne, Zack Moore, Vance G. Fowler

Houston Methodist

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

Whole-genome analysis was applied to investigate atypical point-source transmission of 2 invasive group A streptococcal (GAS) infections. Isolates were serotype M4, ST39, and genetically indistinguishable. Comparison with MGAS10750 revealed nonsynonymous polymorphisms in ropB and increased speB transcription. This study demonstrates the usefulness of whole-genome analyses for GAS outbreaks.

Original language	English (US)
Journal	Open Forum Infectious Diseases
Volume	3
Issue number	1
DOIs	https://doi.org/10.1093/ofid/ofw042
State	Published - Jan 1 2016

Keywords

Group A streptococcus
Invasive disease
Streptococcus pyogenes
Whole-genome sequencing
speB

ASJC Scopus subject areas

Infectious Diseases
Oncology

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10.1093/ofid/ofw042

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title = "Application of whole-genome sequencing to an unusual outbreak of invasive group a streptococcal disease",

abstract = "Whole-genome analysis was applied to investigate atypical point-source transmission of 2 invasive group A streptococcal (GAS) infections. Isolates were serotype M4, ST39, and genetically indistinguishable. Comparison with MGAS10750 revealed nonsynonymous polymorphisms in ropB and increased speB transcription. This study demonstrates the usefulness of whole-genome analyses for GAS outbreaks.",

keywords = "Group A streptococcus, Invasive disease, Streptococcus pyogenes, Whole-genome sequencing, speB",

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AU - Clement, Meredith E.

AU - Kuinkel, Batu K.Sharma

AU - Ruffin, Felicia

AU - Flores, Anthony R.

AU - Levinson, Howard

AU - Shelburne, Samuel A.

AU - Moore, Zack

AU - Fowler, Vance G.

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AB - Whole-genome analysis was applied to investigate atypical point-source transmission of 2 invasive group A streptococcal (GAS) infections. Isolates were serotype M4, ST39, and genetically indistinguishable. Comparison with MGAS10750 revealed nonsynonymous polymorphisms in ropB and increased speB transcription. This study demonstrates the usefulness of whole-genome analyses for GAS outbreaks.

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KW - Invasive disease

KW - Streptococcus pyogenes

KW - Whole-genome sequencing

KW - speB

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Application of whole-genome sequencing to an unusual outbreak of invasive group a streptococcal disease

Abstract

Keywords

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