[Application of steroids minimization immunosuppressive regimen in liver transplantation].

Lin wei Wu, Xiao shun He, Qiang Tai, Wei qiang Ju, Dong ping Wang, Xiao feng Zhu, Y. Ma, Guo dong Wang, An bin Hu, Jie fu Huang

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

To investigate the safety and feasibility of steroids minimization immunosuppressive regimen in liver transplantation. One hundred and sixteen patients in line with the selecting criteria from January 2005 to June 2008 were divided into three groups according to the withdrawal of steroids: 40 cases in 3 months withdrawal group, 40 cases in 7 d withdrawal group and the other 36 cases in 24 h withdrawal group. The difference of recipients' survival, infection, acute rejection and steroids resistant acute rejection, wound healing, recurrence of HBV and hepatocellular cell (HCC), new on-set of diabetes, hyperlipidemia and hypertension between the three groups were compared. The difference of recipients' survival, acute rejection including steroids resistant acute rejection, recurrence of HBV and HCC, hyperlipidemia between the three groups were not significant (P > 0.05), the incidence of wound un-healing and hypertension in 24 h withdrawal group was significantly lower than that in the other 2 groups (P < 0.05), the incidence of infection and new on-set diabetes in 24 h withdrawal group and 7 d withdrawal group was significantly lower than that in 3 months withdrawal group (P < 0.05). Steroids minimization immunosuppressive strategy is safe and feasible in liver transplantation field, it will significantly reduce the steroids related complications without increasing the risk of rejection.

Original languageEnglish (US)
Pages (from-to)492-495
Number of pages4
JournalZhonghua wai ke za zhi [Chinese journal of surgery]
Volume48
Issue number7
StatePublished - Apr 1 2010

ASJC Scopus subject areas

  • Medicine(all)

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