TY - JOUR
T1 - Application of multifunctional nanomaterials in tumor radiosensitization
AU - Gong, Linji
AU - Xie, Jiani
AU - Zhu, Shuang
AU - Gu, Zhanjun
AU - Zhao, Yuliang
N1 - Funding Information:
Received: May 29, 2017; Revised: June 28, 2017; Accepted: June 30, 2017: Published online: July 17, 2017. *Corresponding authors. Email: zjgu@ihep.ac.cn; Tel.: +86-10-88236786 (G.Z.J.). Email: zhaoyl@nanoctr.cn; Tel.: +86-10-82545570 (Z.Y.L.). The project was supported by the National Basic Research Programs of China (2016YFA0201600, 2016YFA0202104, 2015CB932104), National Natural Science Foundation of China (31571015, 11621505, 11435002, 21320102003) and Youth Innovation Promotion Association of Chinese Academy of Sciences (2013007). 国家重点基础研究发展计划(2016YFA0201600, 2016YFA0202104, 2015CB932104), 国家自然科学基金(31571015, 11621505, 11435002, 21320102003) 及中国科学院青年创新促进会基金(2013007)资助
Publisher Copyright:
© Editorial office of Acta Physico-Chimica Sinica.
Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.
PY - 2018
Y1 - 2018
N2 - Radiation therapy kills tumor cells via focused high energy radiation, and has become one of the most common and effective clinical treatments for malignant tumors. However, some limitations restrict its clinical efficacy, including a requirement for elevated doses of radiation, side effects due to exposure of healthy tissue, and especially radioresistance of tumor cells. With the development of nanomedicine, multifunctional nanoradiosensitizers offer a new route to improve the efficiency of radiation therapy. In this paper, we summarize the main types of nanoradiosensitizers and their applications in radiation therapy, especially those that have currently entered clinical trials. We also summarize the main approaches to nanomaterials-based radiosensitization, and discuss the factors influencing their application. Finally, the challenges and prospects of multifunctional nanoradiosensitizers are presented.
AB - Radiation therapy kills tumor cells via focused high energy radiation, and has become one of the most common and effective clinical treatments for malignant tumors. However, some limitations restrict its clinical efficacy, including a requirement for elevated doses of radiation, side effects due to exposure of healthy tissue, and especially radioresistance of tumor cells. With the development of nanomedicine, multifunctional nanoradiosensitizers offer a new route to improve the efficiency of radiation therapy. In this paper, we summarize the main types of nanoradiosensitizers and their applications in radiation therapy, especially those that have currently entered clinical trials. We also summarize the main approaches to nanomaterials-based radiosensitization, and discuss the factors influencing their application. Finally, the challenges and prospects of multifunctional nanoradiosensitizers are presented.
KW - Nanomedicine
KW - Nanoradiosensitizer
KW - Radiation therapy
KW - Radiosensitization mechanism
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U2 - 10.3866/PKU.WHXB201707174
DO - 10.3866/PKU.WHXB201707174
M3 - Review article
AN - SCOPUS:85034432296
VL - 34
SP - 140
EP - 167
JO - Wuli Huaxue Xuebao/ Acta Physico - Chimica Sinica
JF - Wuli Huaxue Xuebao/ Acta Physico - Chimica Sinica
SN - 1000-6818
IS - 2
ER -