TY - JOUR
T1 - Application of in silico Platform for the Development and Optimization of Fully Bioresorbable Vascular Scaffold Designs
AU - Milosevic, Miljan
AU - Anic, Milos
AU - Nikolic, Dalibor
AU - Geroski, Vladimir
AU - Milicevic, Bogdan
AU - Kojic, Milos
AU - Filipovic, Nenad
N1 - Funding Information:
This research is supported by the European Union's Horizon 2020 research and innovation programme under grant agreements No 777119 ( https://insilc.eu/ ) and No 956470 ( https://www.decodeitn.eu/ ). This article reflects only the author's view. The Commission is not responsible for any use that may be made of the information it contains. The research was also funded by Serbian Ministry of Education, Science, and Technological Development, grants [451-03-9/2021-14/200378 (Institute for Information Technologies, University of Kragujevac)] and [451-03-9/2021-14/200107 (Faculty of Engineering, University of Kragujevac)].
Funding Information:
The authors acknowledge the support from the City of Kragujevac, Serbia.
Publisher Copyright:
Copyright © 2021 Milosevic, Anic, Nikolic, Geroski, Milicevic, Kojic and Filipovic.
PY - 2021/10/14
Y1 - 2021/10/14
N2 - Bioresorbable vascular scaffolds (BVS), made either from polymers or from metals, are promising materials for treating coronary artery disease through the processes of percutaneous transluminal coronary angioplasty. Despite the opinion that bioresorbable polymers are more promising for coronary stents, their long-term advantages over metallic alloys have not yet been demonstrated. The development of new polymer-based BVS or optimization of the existing ones requires engineers to perform many very expensive mechanical tests to identify optimal structural geometry and material characteristics. in silico mechanical testing opens the possibility for a fast and low-cost process of analysis of all the mechanical characteristics and also provides the possibility to compare two or more competing designs. In this study, we used a recently introduced material model of poly-l-lactic acid (PLLA) fully bioresorbable vascular scaffold and recently empowered numerical InSilc platform to perform in silico mechanicals tests of two different stent designs with different material and geometrical characteristics. The result of inflation, radial compression, three-point bending, and two-plate crush tests shows that numerical procedures with true experimental constitutive relationships could provide reliable conclusions and a significant contribution to the optimization and design of bioresorbable polymer-based stents.
AB - Bioresorbable vascular scaffolds (BVS), made either from polymers or from metals, are promising materials for treating coronary artery disease through the processes of percutaneous transluminal coronary angioplasty. Despite the opinion that bioresorbable polymers are more promising for coronary stents, their long-term advantages over metallic alloys have not yet been demonstrated. The development of new polymer-based BVS or optimization of the existing ones requires engineers to perform many very expensive mechanical tests to identify optimal structural geometry and material characteristics. in silico mechanical testing opens the possibility for a fast and low-cost process of analysis of all the mechanical characteristics and also provides the possibility to compare two or more competing designs. In this study, we used a recently introduced material model of poly-l-lactic acid (PLLA) fully bioresorbable vascular scaffold and recently empowered numerical InSilc platform to perform in silico mechanicals tests of two different stent designs with different material and geometrical characteristics. The result of inflation, radial compression, three-point bending, and two-plate crush tests shows that numerical procedures with true experimental constitutive relationships could provide reliable conclusions and a significant contribution to the optimization and design of bioresorbable polymer-based stents.
KW - bioresorbable PLLA stent
KW - design and optimization
KW - finite element analysis
KW - in vitro mechanical test
KW - vascular scaffold
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U2 - 10.3389/fmedt.2021.724062
DO - 10.3389/fmedt.2021.724062
M3 - Article
AN - SCOPUS:85138448225
SN - 2673-3129
VL - 3
JO - Frontiers in Medical Technology
JF - Frontiers in Medical Technology
M1 - 724062
ER -