Application of immunohistochemistry to the diagnosis of kidney tumors

Hayma Al-Ghawi; Oluyomi A. Asojo; Luan D. Truong; Jae Y. Ro; Alberto G. Ayala; Qihui Jim Zhai

doi:10.1097/PCR.0b013e3181d51c70

Application of immunohistochemistry to the diagnosis of kidney tumors

Hayma Al-Ghawi, Oluyomi A. Asojo, Luan D. Truong, Jae Y. Ro, Alberto G. Ayala, Qihui Jim Zhai

Research output: Contribution to journal › Review article › peer-review

4 Scopus citations

Abstract

Multiple morphologic subtypes of renal cell carcinoma exist and management protocols are dependent on each subtype. Therefore, it is paramount to distinguish one subtype from another. In the setting of metastatic carcinoma, primarily kidney should be considered with the appropriate histologic features. Diagnostic immunohistochemistry (IHC) is crucial in these clinical settings. Immunohistochemical stains such as RCCM, CD10, cadherins, PAX-2, PAX-8, cytokeratins, vimentin, EMA, c-Kit, TFE-3, and alpha-methylacyl-CoA racemase in addition to other IHC markers serve as essential tools to the surgical pathologist. This article addresses the frequently used IHC markers and their applications in common diagnostic problems encountered in the diagnosis of kidney tumors.

Original language	English (US)
Pages (from-to)	25-34
Number of pages	10
Journal	Pathology Case Reviews
Volume	15
Issue number	1
DOIs	https://doi.org/10.1097/PCR.0b013e3181d51c70
State	Published - Jan 2010

Keywords

Differential diagnosis
Immunohistochemistry
RCC

ASJC Scopus subject areas

Pathology and Forensic Medicine

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10.1097/PCR.0b013e3181d51c70

Cite this

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title = "Application of immunohistochemistry to the diagnosis of kidney tumors",

abstract = "Multiple morphologic subtypes of renal cell carcinoma exist and management protocols are dependent on each subtype. Therefore, it is paramount to distinguish one subtype from another. In the setting of metastatic carcinoma, primarily kidney should be considered with the appropriate histologic features. Diagnostic immunohistochemistry (IHC) is crucial in these clinical settings. Immunohistochemical stains such as RCCM, CD10, cadherins, PAX-2, PAX-8, cytokeratins, vimentin, EMA, c-Kit, TFE-3, and alpha-methylacyl-CoA racemase in addition to other IHC markers serve as essential tools to the surgical pathologist. This article addresses the frequently used IHC markers and their applications in common diagnostic problems encountered in the diagnosis of kidney tumors.",

keywords = "Differential diagnosis, Immunohistochemistry, RCC",

author = "Hayma Al-Ghawi and Asojo, \{Oluyomi A.\} and Truong, \{Luan D.\} and Ro, \{Jae Y.\} and Ayala, \{Alberto G.\} and Zhai, \{Qihui Jim\}",

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AU - Al-Ghawi, Hayma

AU - Asojo, Oluyomi A.

AU - Truong, Luan D.

AU - Ro, Jae Y.

AU - Ayala, Alberto G.

AU - Zhai, Qihui Jim

PY - 2010/1

Y1 - 2010/1

N2 - Multiple morphologic subtypes of renal cell carcinoma exist and management protocols are dependent on each subtype. Therefore, it is paramount to distinguish one subtype from another. In the setting of metastatic carcinoma, primarily kidney should be considered with the appropriate histologic features. Diagnostic immunohistochemistry (IHC) is crucial in these clinical settings. Immunohistochemical stains such as RCCM, CD10, cadherins, PAX-2, PAX-8, cytokeratins, vimentin, EMA, c-Kit, TFE-3, and alpha-methylacyl-CoA racemase in addition to other IHC markers serve as essential tools to the surgical pathologist. This article addresses the frequently used IHC markers and their applications in common diagnostic problems encountered in the diagnosis of kidney tumors.

AB - Multiple morphologic subtypes of renal cell carcinoma exist and management protocols are dependent on each subtype. Therefore, it is paramount to distinguish one subtype from another. In the setting of metastatic carcinoma, primarily kidney should be considered with the appropriate histologic features. Diagnostic immunohistochemistry (IHC) is crucial in these clinical settings. Immunohistochemical stains such as RCCM, CD10, cadherins, PAX-2, PAX-8, cytokeratins, vimentin, EMA, c-Kit, TFE-3, and alpha-methylacyl-CoA racemase in addition to other IHC markers serve as essential tools to the surgical pathologist. This article addresses the frequently used IHC markers and their applications in common diagnostic problems encountered in the diagnosis of kidney tumors.

KW - Differential diagnosis

KW - Immunohistochemistry

KW - RCC

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Application of immunohistochemistry to the diagnosis of kidney tumors

Abstract

Keywords

ASJC Scopus subject areas

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