Application of immunohistochemistry to the diagnosis of kidney tumors

Hayma Al-Ghawi, Oluyomi A. Asojo, Luan D. Truong, Jae Y. Ro, Alberto G. Ayala, Qihui Jim Zhai

Research output: Contribution to journalReview articlepeer-review

4 Scopus citations


Multiple morphologic subtypes of renal cell carcinoma exist and management protocols are dependent on each subtype. Therefore, it is paramount to distinguish one subtype from another. In the setting of metastatic carcinoma, primarily kidney should be considered with the appropriate histologic features. Diagnostic immunohistochemistry (IHC) is crucial in these clinical settings. Immunohistochemical stains such as RCCM, CD10, cadherins, PAX-2, PAX-8, cytokeratins, vimentin, EMA, c-Kit, TFE-3, and alpha-methylacyl-CoA racemase in addition to other IHC markers serve as essential tools to the surgical pathologist. This article addresses the frequently used IHC markers and their applications in common diagnostic problems encountered in the diagnosis of kidney tumors.

Original languageEnglish (US)
Pages (from-to)25-34
Number of pages10
JournalPathology Case Reviews
Issue number1
StatePublished - Jan 2010


  • Differential diagnosis
  • Immunohistochemistry
  • RCC

ASJC Scopus subject areas

  • Pathology and Forensic Medicine


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