Multiple morphologic subtypes of renal cell carcinoma exist and management protocols are dependent on each subtype. Therefore, it is paramount to distinguish one subtype from another. In the setting of metastatic carcinoma, primarily kidney should be considered with the appropriate histologic features. Diagnostic immunohistochemistry (IHC) is crucial in these clinical settings. Immunohistochemical stains such as RCCM, CD10, cadherins, PAX-2, PAX-8, cytokeratins, vimentin, EMA, c-Kit, TFE-3, and alpha-methylacyl-CoA racemase in addition to other IHC markers serve as essential tools to the surgical pathologist. This article addresses the frequently used IHC markers and their applications in common diagnostic problems encountered in the diagnosis of kidney tumors.
- Differential diagnosis
ASJC Scopus subject areas
- Pathology and Forensic Medicine