TY - JOUR
T1 - Application of immunohistochemistry to the diagnosis of kidney tumors
AU - Al-Ghawi, Hayma
AU - Asojo, Oluyomi A.
AU - Truong, Luan D.
AU - Ro, Jae Y.
AU - Ayala, Alberto G.
AU - Zhai, Qihui Jim
N1 - Copyright:
Copyright 2010 Elsevier B.V., All rights reserved.
PY - 2010/1
Y1 - 2010/1
N2 - Multiple morphologic subtypes of renal cell carcinoma exist and management protocols are dependent on each subtype. Therefore, it is paramount to distinguish one subtype from another. In the setting of metastatic carcinoma, primarily kidney should be considered with the appropriate histologic features. Diagnostic immunohistochemistry (IHC) is crucial in these clinical settings. Immunohistochemical stains such as RCCM, CD10, cadherins, PAX-2, PAX-8, cytokeratins, vimentin, EMA, c-Kit, TFE-3, and alpha-methylacyl-CoA racemase in addition to other IHC markers serve as essential tools to the surgical pathologist. This article addresses the frequently used IHC markers and their applications in common diagnostic problems encountered in the diagnosis of kidney tumors.
AB - Multiple morphologic subtypes of renal cell carcinoma exist and management protocols are dependent on each subtype. Therefore, it is paramount to distinguish one subtype from another. In the setting of metastatic carcinoma, primarily kidney should be considered with the appropriate histologic features. Diagnostic immunohistochemistry (IHC) is crucial in these clinical settings. Immunohistochemical stains such as RCCM, CD10, cadherins, PAX-2, PAX-8, cytokeratins, vimentin, EMA, c-Kit, TFE-3, and alpha-methylacyl-CoA racemase in addition to other IHC markers serve as essential tools to the surgical pathologist. This article addresses the frequently used IHC markers and their applications in common diagnostic problems encountered in the diagnosis of kidney tumors.
KW - Differential diagnosis
KW - Immunohistochemistry
KW - RCC
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U2 - 10.1097/PCR.0b013e3181d51c70
DO - 10.1097/PCR.0b013e3181d51c70
M3 - Review article
AN - SCOPUS:77649092464
VL - 15
SP - 25
EP - 34
JO - Pathology Case Reviews
JF - Pathology Case Reviews
SN - 1082-9784
IS - 1
ER -