Application of Composite Smeared Finite Element Model in Drug Delivery Inside Organs

Vladimir Simic, Miljan Milosevic, Arturas Ziemys, Milos Kojic

Research output: Chapter in Book/Report/Conference proceedingChapter


We here implement the smeared field finite element methodology, formulated by the last listed author, which is presented in numerous of recent publications. This methodology enables modeling physical fields in biological systems in a simple way, which otherwise, by detailed representation of each biological constituents (capillaries, cell membranes, cell interior, etc.), would not be practical to use. Here we summarize the basic concept of the smeared modeling by describing briefly formulation of a composite smeared finite element (CSFE). Besides the standard FE representation of continuum fields of molecular transport, 1D transport is included in a continuum form using the appropriate transport tensors. Physical fields are coupled by the connectivity elements at each node, representing transport properties of the walls separating the domains. In this paper, methodology is applied to determine concentration field within liver of a mouse, generated from images, containing a tumor. Also, evolution of drug concentration within tumor is presented, which is important for improvement of cancer therapy.

Original languageEnglish (US)
Title of host publicationLearning and Analytics in Intelligent Systems
PublisherSpringer Nature
Number of pages9
StatePublished - 2020

Publication series

NameLearning and Analytics in Intelligent Systems
ISSN (Print)2662-3447
ISSN (Electronic)2662-3455

ASJC Scopus subject areas

  • Artificial Intelligence
  • Computer Science Applications
  • Computer Vision and Pattern Recognition
  • Control and Systems Engineering


Dive into the research topics of 'Application of Composite Smeared Finite Element Model in Drug Delivery Inside Organs'. Together they form a unique fingerprint.

Cite this