Apoptosis of Th1-like cells in experimental tuberculosis (TB)

G. Das, H. Vohra, B. Saha, J. N. Agrewala, G. C. Mishra

Research output: Contribution to journalArticle

41 Scopus citations

Abstract

Th1 cell-induced anti-mycobacterial immunity is lost during a progressive Mycobacterium tuberculosi infection in a susceptible host. This study was designed to test the mechanism of the loss of antimycobacterial cell-mediated immune response. We demonstrate that M. tuberculosis infection results in increased Fas expression and decreased Bcl-2 expression in CD4+ T cells. When CD4+ T cells are stimulated in vitro, they show increased apoptosis and decreased production of IL-2 and interferon gamma (IFN-γ) but not of IL-4. These changes may result in selective apoptosis of Th1-like cells leading to the loss of cell-mediated immune response against M. tuberculosis.

Original languageEnglish (US)
Pages (from-to)324-328
Number of pages5
JournalClinical and Experimental Immunology
Volume115
Issue number2
DOIs
StatePublished - 1999

Keywords

  • Apoptosis tuberculosis
  • Fas Bcl-2
  • Th1 cells

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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