Apoptosis of Th1-like cells in experimental tuberculosis (TB)

G. Das; H. Vohra; B. Saha; J. N. Agrewala; G. C. Mishra

doi:10.1046/j.1365-2249.1999.00755.x

Apoptosis of Th1-like cells in experimental tuberculosis (TB)

G. Das, H. Vohra, B. Saha, J. N. Agrewala, G. C. Mishra

Research output: Contribution to journal › Article › peer-review

44 Scopus citations

Abstract

Th1 cell-induced anti-mycobacterial immunity is lost during a progressive Mycobacterium tuberculosi infection in a susceptible host. This study was designed to test the mechanism of the loss of antimycobacterial cell-mediated immune response. We demonstrate that M. tuberculosis infection results in increased Fas expression and decreased Bcl-2 expression in CD4⁺ T cells. When CD4⁺ T cells are stimulated in vitro, they show increased apoptosis and decreased production of IL-2 and interferon gamma (IFN-γ) but not of IL-4. These changes may result in selective apoptosis of Th1-like cells leading to the loss of cell-mediated immune response against M. tuberculosis.

Original language	English (US)
Pages (from-to)	324-328
Number of pages	5
Journal	Clinical and Experimental Immunology
Volume	115
Issue number	2
DOIs	https://doi.org/10.1046/j.1365-2249.1999.00755.x
State	Published - 1999

Keywords

Apoptosis tuberculosis
Fas Bcl-2
Th1 cells

ASJC Scopus subject areas

Immunology and Allergy
Immunology

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10.1046/j.1365-2249.1999.00755.x

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abstract = "Th1 cell-induced anti-mycobacterial immunity is lost during a progressive Mycobacterium tuberculosi infection in a susceptible host. This study was designed to test the mechanism of the loss of antimycobacterial cell-mediated immune response. We demonstrate that M. tuberculosis infection results in increased Fas expression and decreased Bcl-2 expression in CD4+ T cells. When CD4+ T cells are stimulated in vitro, they show increased apoptosis and decreased production of IL-2 and interferon gamma (IFN-γ) but not of IL-4. These changes may result in selective apoptosis of Th1-like cells leading to the loss of cell-mediated immune response against M. tuberculosis.",

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AU - Vohra, H.

AU - Saha, B.

AU - Agrewala, J. N.

AU - Mishra, G. C.

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AB - Th1 cell-induced anti-mycobacterial immunity is lost during a progressive Mycobacterium tuberculosi infection in a susceptible host. This study was designed to test the mechanism of the loss of antimycobacterial cell-mediated immune response. We demonstrate that M. tuberculosis infection results in increased Fas expression and decreased Bcl-2 expression in CD4+ T cells. When CD4+ T cells are stimulated in vitro, they show increased apoptosis and decreased production of IL-2 and interferon gamma (IFN-γ) but not of IL-4. These changes may result in selective apoptosis of Th1-like cells leading to the loss of cell-mediated immune response against M. tuberculosis.

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Apoptosis of Th1-like cells in experimental tuberculosis (TB)

Abstract

Keywords

ASJC Scopus subject areas

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