Apoptosis of Th1-like cells in experimental tuberculosis (TB)

Gobardhan Das, H. Vohra, B. Saha, J. N. Agrewala, G. C. Mishra

Research output: Contribution to journalArticle

Abstract

Th1 cell-induced anti-mycobacterial immunity is lost during a progressive Mycobacterium tuberculosis infection in a susceptible host. This study was designed to test the mechanism of the loss of anti-mycobacterial cell-mediated immune response. We demonstrate that M. tuberculosis infection results in increased Fas expression and decreased Bc1-2 expression in CD4+ T cells. When CD4+ T cells are stimulated in vitro, they show increased apoptosis and decreased production of IL-2 and interferon-gamma but not of IL-4. These changes may result in selective apoptosis of Th1-like cells, leading to the loss of cell-mediated immune response against M. tuberculosis.

Original languageEnglish (US)
Pages (from-to)501-502
Number of pages2
JournalInternational Journal of Leprosy and Other Mycobacterial Diseases
Volume67
Issue number4 SUPPL.
StatePublished - Dec 1 1999

ASJC Scopus subject areas

  • Dermatology

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