Apoptosis of Th1-like cells in experimental tuberculosis (TB)

Gobardhan Das; H. Vohra; B. Saha; J. N. Agrewala; G. C. Mishra

Apoptosis of Th1-like cells in experimental tuberculosis (TB)

Gobardhan Das, H. Vohra, B. Saha, J. N. Agrewala, G. C. Mishra

Research output: Contribution to journal › Article › peer-review

Abstract

Th1 cell-induced anti-mycobacterial immunity is lost during a progressive Mycobacterium tuberculosis infection in a susceptible host. This study was designed to test the mechanism of the loss of anti-mycobacterial cell-mediated immune response. We demonstrate that M. tuberculosis infection results in increased Fas expression and decreased Bc1-2 expression in CD4+ T cells. When CD4+ T cells are stimulated in vitro, they show increased apoptosis and decreased production of IL-2 and interferon-gamma but not of IL-4. These changes may result in selective apoptosis of Th1-like cells, leading to the loss of cell-mediated immune response against M. tuberculosis.

Original language	English (US)
Pages (from-to)	501-502
Number of pages	2
Journal	International Journal of Leprosy and Other Mycobacterial Diseases
Volume	67
Issue number	4 SUPPL.
State	Published - Dec 1 1999

ASJC Scopus subject areas

Dermatology

Cite this

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title = "Apoptosis of Th1-like cells in experimental tuberculosis (TB)",

abstract = "Th1 cell-induced anti-mycobacterial immunity is lost during a progressive Mycobacterium tuberculosis infection in a susceptible host. This study was designed to test the mechanism of the loss of anti-mycobacterial cell-mediated immune response. We demonstrate that M. tuberculosis infection results in increased Fas expression and decreased Bc1-2 expression in CD4+ T cells. When CD4+ T cells are stimulated in vitro, they show increased apoptosis and decreased production of IL-2 and interferon-gamma but not of IL-4. These changes may result in selective apoptosis of Th1-like cells, leading to the loss of cell-mediated immune response against M. tuberculosis.",

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AU - Das, Gobardhan

AU - Vohra, H.

AU - Saha, B.

AU - Agrewala, J. N.

AU - Mishra, G. C.

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N2 - Th1 cell-induced anti-mycobacterial immunity is lost during a progressive Mycobacterium tuberculosis infection in a susceptible host. This study was designed to test the mechanism of the loss of anti-mycobacterial cell-mediated immune response. We demonstrate that M. tuberculosis infection results in increased Fas expression and decreased Bc1-2 expression in CD4+ T cells. When CD4+ T cells are stimulated in vitro, they show increased apoptosis and decreased production of IL-2 and interferon-gamma but not of IL-4. These changes may result in selective apoptosis of Th1-like cells, leading to the loss of cell-mediated immune response against M. tuberculosis.

AB - Th1 cell-induced anti-mycobacterial immunity is lost during a progressive Mycobacterium tuberculosis infection in a susceptible host. This study was designed to test the mechanism of the loss of anti-mycobacterial cell-mediated immune response. We demonstrate that M. tuberculosis infection results in increased Fas expression and decreased Bc1-2 expression in CD4+ T cells. When CD4+ T cells are stimulated in vitro, they show increased apoptosis and decreased production of IL-2 and interferon-gamma but not of IL-4. These changes may result in selective apoptosis of Th1-like cells, leading to the loss of cell-mediated immune response against M. tuberculosis.

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Apoptosis of Th1-like cells in experimental tuberculosis (TB)

Abstract

ASJC Scopus subject areas

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