Lipoprotein lipase (LPL) has a vital role in regulating the catabolism of the triglyceride-rich lipoproteins, which are the chylomicrons and the very-low-density lipoproteins (VLDL)1; LPL catalyzes the hydrolysis of chylomicron and VLDL triglyceride — a crucial step in their extrahepatic catabolism. Since intravenous administration of heparin releases LPL and other enzymes into the plasma, LPL is thought to be an exoenzyme located on the surface of the endothelial cell. Whether LPL is transported to that site from other tissues of the body, as seems likely, or whether it is synthesized by the endothelial cells is not known. Unlike the.
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