Aortic impedance in Little mice

Anilkumar K. Reddy, George E. Taffet, Craig J. Hartley

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Scopus citations

Abstract

The Little dwarf mouse lives 30% longer than its age-matched wild-type (WT) mouse. We determined aortic input impedance in 21 (8 Little, 13 WT) 4 month-old mice. Modulus of impedance was calculated from the Fourier transformed aortic pressure (P) and average luminal flow velocity (V(avg)) as |Z(i)| = |P|/|V(avg)|. Characteristic impedance was estimated by averaging the 2(nd)-10(th) harmonic of the impedance moduli. We found the impedance modulus |Z(i)| to be similar in the 2 groups (WT vs. Little; mean+/-SE) - peripheral resistance (10597+/-654 vs. 12932+/-1433 dyne-s/cm(3)), modulus at first harmonic (Z(1): 740+/-56 vs. 902+/-105 dyne-s/cm(3)), and characteristic impedance (Z(c): 441+/-34 vs. 470+/-60 dyne-s/cm(3)). Also, mean aortic velocity (20.1+/-1.1 vs. 16.5+/-1.8 cm/s) and mean aortic blood pressure (81.1+/-3.9 vs. 75.9+/-5.9 mmHg) were similar between the two groups. Impedance at low frequencies was slightly higher in the dwarf mice which may be due to the diminished systolic function as indicated by significant reduction in peak aortic velocity (84.0+/-3.2 vs. 70.1+/-1.2 cm/s, p<<0.01). Although modestly higher, the overall impedance in Little mice was similar to that in WT mice. This indicates that left ventricular (LV) afterload may not significantly be altered in Little mice.

Original languageEnglish
Title of host publicationProceedings of the 30th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'08 - "Personalized Healthcare through Technology"
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages1397-1398
Number of pages2
ISBN (Print)9781424418152
StatePublished - Dec 1 2008
Event30th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'08 - Vancouver, BC, Canada
Duration: Aug 20 2008Aug 25 2008

Other

Other30th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'08
CountryCanada
CityVancouver, BC
Period8/20/088/25/08

Keywords

  • Aortic impedance
  • Blood flow velocity
  • Blood pressure
  • Little mouse

ASJC Scopus subject areas

  • Computer Vision and Pattern Recognition
  • Signal Processing
  • Biomedical Engineering
  • Health Informatics

Fingerprint Dive into the research topics of 'Aortic impedance in Little mice'. Together they form a unique fingerprint.

Cite this