Antiplatelet therapy in acute coronary syndromes

Colin M. Barker, Matthew J. Price

Research output: Contribution to journalReview articlepeer-review

5 Scopus citations


Acute coronary syndromes (ACS), characterized by unstable angina or a non-ST-segment elevation myocardial infarction, are caused by rupture of an atherosclerotic plaque, leading to platelet activation and aggregation, thrombus formation, and microembolization. Antiplatelet therapy is a cornerstone of therapy. Combined with aspirin, clopidogrel provides significant benefit for patients across the ACS spectrum. However, clopidogrel has limitations given its slow onset and the inconsistent level of inhibition that it achieves. Newer thienopyridine and non-thienopyridine P2Y12 receptor agonists offer the advantages of a rapid onset of action and greater and more consistent platelet inhibition.

Original languageEnglish (US)
Pages (from-to)327-333
Number of pages7
JournalCurrent Cardiology Reports
Issue number4
StatePublished - 2008

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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