Antimicrobial factors and bacterial correlation in chronic otitis media with effusion

R. W. Lang, Y. S. Liu, D. J. Lim, H. G. Birck

Research output: Contribution to journalArticlepeer-review

15 Scopus citations


Analyses of effusions and sera from patients with otitis media with effusion demonstrated local production in the middle ear of lysozyme, IgA and IgG. The effusion IgM was markedly elevated in some patients, also indicating local production. Complement C3 with rare exception was significantly lower in effusions than sera, suggesting utilization of complement in the middle ear, perhaps in conjunction with antibodies. The presence of high levels of lysozyme and immunoglobulins in effusions correlates with the low isolation rate of microorganisms in culture and may influence survival of organisms in the middle ear.

Original languageEnglish (US)
Pages (from-to)145-151
Number of pages7
JournalAnnals of Otology, Rhinology and Laryngology
Issue numberSup.25
StatePublished - 1976

ASJC Scopus subject areas

  • Otorhinolaryngology


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