Antimicrobial activity and durability of a novel antimicrobial-impregnated bladder catheter

R. O. Darouiche, O. Z. Hampel, Timothy B. Boone, I. I. Raad

Research output: Contribution to journalArticle

16 Scopus citations

Abstract

The main objective of this study was to examine the antimicrobial activity and durability of a novel indwelling bladder catheter impregnated with minocycline and rifampin. Thirty antimicrobial-impregnated bladder catheters were inserted transurethrally in spinal cord-injured patients and removed, in six groups of five catheters each, at 3, 7, 10, 14, 17 or 21 days. Removed catheters had detectable zones of inhibition against two different clinical isolates of each of the 10 tested uropathogens (Escherichia coli, Pseudomonas aeruginosa, Proteus mirabilis, Klebsiella pneumoniae, Enterobacter cloacae, Citrobacter diversus, Enterococcus faecalis, Enterococcus faecium, Staphylococcus saprophyticus and Candina albicans) for greater than 14 days after catheter insertion. The residual zones of inhibition and levels of antimicrobial agents in removed catheters were both inversely related to the duration of catheter placement. Minocycline and rifampin were undetectable in serum and urine. These results support the ongoing efforts for examining the clinical efficacy of these experimental bladder catheters.

Original languageEnglish (US)
Pages (from-to)243-247
Number of pages5
JournalInternational Journal of Antimicrobial Agents
Volume8
Issue number4
DOIs
StatePublished - 1997

Keywords

  • Antimicrobial activity
  • Antimicrobial impregnation
  • Bladder catheter

ASJC Scopus subject areas

  • Applied Microbiology and Biotechnology
  • Microbiology
  • Parasitology
  • Virology
  • Immunology and Allergy
  • Infectious Diseases

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