Antimicrobial activities of beta-lactam antibiotics and gentamicin against penicillin-susceptible and penicillin-resistant pneumococci

M. E. Gross; K. P. Giron; J. D. Septimus; E. O. Mason; D. M. Musher

doi:10.1128/AAC.39.5.1166

Antimicrobial activities of beta-lactam antibiotics and gentamicin against penicillin-susceptible and penicillin-resistant pneumococci

M. E. Gross, K. P. Giron, J. D. Septimus, E. O. Mason, D. M. Musher

Research output: Contribution to journal › Article › peer-review

23 Scopus citations

Abstract

The MICs of penicillin and cefotaxime for a range of penicillin- susceptible and penicillin-resistant isolates of Streptococcus pneumoniae were unchanged by the addition of gentamicin. In time-kill studies the rate of killing was greater for 18 of 20 isolates in the presence of gentamicin. However, mean differences in killing after 6 h of incubation were modest, not exceeding 1 log₁₀ unit.

Original language	English (US)
Pages (from-to)	1166-1168
Number of pages	3
Journal	Antimicrobial Agents and Chemotherapy
Volume	39
Issue number	5
DOIs	https://doi.org/10.1128/AAC.39.5.1166
State	Published - 1995

ASJC Scopus subject areas

Pharmacology
Pharmacology (medical)
Infectious Diseases

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abstract = "The MICs of penicillin and cefotaxime for a range of penicillin- susceptible and penicillin-resistant isolates of Streptococcus pneumoniae were unchanged by the addition of gentamicin. In time-kill studies the rate of killing was greater for 18 of 20 isolates in the presence of gentamicin. However, mean differences in killing after 6 h of incubation were modest, not exceeding 1 log10 unit.",

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AU - Musher, D. M.

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Antimicrobial activities of beta-lactam antibiotics and gentamicin against penicillin-susceptible and penicillin-resistant pneumococci

Abstract

ASJC Scopus subject areas

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