Anti‐Idiotypic B Lymphocytes in Patients with Monoclonal Gammopathies

S. BERGENBRANT, Qing Yi, E. ÖSBY, A. ÖSTERBORG, R. ÖSTMAN, M. BJÖRKHOLM, G. HOLM, A. K. LEFVERT

Research output: Contribution to journalArticle

17 Scopus citations

Abstract

The prevalence of peripheral blood B cells secreting antibodies reacting with the F(ab')2 fragment of monoclonal IgG was studied in five patients with multiple myeloma (MM), nine patients with monoclonal gammopathy of undetermined significance (MGUS) and six healthy controls. An enzyme‐linked immunospot assay allowed direct visualization of antibody producing B cells. All patients had B cells producing antibodies to autologous or ailogeneic monoclonal IgG. Autoreactive cells were found more frequently than alloreactive cells in seven out of nine patients with MGUS and three out of four patients with MM. The same frequency of alloreactive cells in the patient groups was detected in healthy individuals. These findings show the existence of B cells producing anti‐idiotypic antibodies which could be a part of an idiotypic network in monoclonal gammopathies

Original languageEnglish (US)
Pages (from-to)216-220
Number of pages5
JournalScandinavian Journal of Immunology
Volume40
Issue number2
DOIs
StatePublished - Jan 1 1994

ASJC Scopus subject areas

  • Immunology

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