Antigenic relationships among frog viruses demonstrated by the plaque reduction and neutralization kinetics tests

Daniel E. Lehane, H. Fred Clark, David T. Karzon

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

Antisera to several different cytoplasmic frog virus isolates were prepared in rabbits. Comparison of eight virus isolates by means of 50% plaque reduction tests revealed no antigenic differences. In neutralization kinetic studies of three isolates, LT-1, LT-2, and FV-1, very low neutralization rate constants (K = 0.18-2.9) and high persistent fractions of nonneutralizable virus (14-38%) were obtained. No antigenic differences were detected, although one isolate, LT-2, consistently gave lower K values and higher persistent fractions with homologous and heterologous sera than did LT-1 and FV-1. It is concluded that all the cytoplasmic frog viruses studied, originating from normal and tumor-bearing frogs from widely separated parts of the United States, comprise a single serotype.

Original languageEnglish (US)
Pages (from-to)590-595
Number of pages6
JournalVirology
Volume34
Issue number4
DOIs
StatePublished - Jan 1 1968

ASJC Scopus subject areas

  • Virology

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