Antigen-specific CD4+ regulatory T cells in cancer: implications for immunotherapy

Helen Yicheng Wang, Rongfu Wang

Research output: Contribution to journalShort surveypeer-review

25 Scopus citations


Regulatory T cells play essential roles in inducing self-tolerance by suppressing immune responses against self such as autoantigens or non-self-antigens such as tumor and pathogenic antigens. Despite the importance of CD4+ regulatory T cells in many immune-related diseases, their antigen specificity and suppressive mechanisms remain elusive. This review discusses the natural ligands and their potential roles of tumor-specific CD4+ regulatory T cells in cancer therapy.

Original languageEnglish (US)
Pages (from-to)1056-1062
Number of pages7
JournalMicrobes and Infection
Issue number7-8
StatePublished - Jun 2005


  • Cancer vaccines
  • CD4 lymphocytes
  • Foxp3
  • Immune suppression
  • Immunotherapy
  • Regulatory T cells
  • Tumor immunology

ASJC Scopus subject areas

  • Microbiology
  • Infectious Diseases


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