Antigen-specific CD4+ regulatory T cells in cancer: implications for immunotherapy

Helen Yicheng Wang; Rongfu Wang

doi:10.1016/j.micinf.2005.03.028

Antigen-specific CD4⁺ regulatory T cells in cancer: implications for immunotherapy

Helen Yicheng Wang, Rongfu Wang

Research output: Contribution to journal › Short survey › peer-review

25 Scopus citations

Abstract

Regulatory T cells play essential roles in inducing self-tolerance by suppressing immune responses against self such as autoantigens or non-self-antigens such as tumor and pathogenic antigens. Despite the importance of CD4⁺ regulatory T cells in many immune-related diseases, their antigen specificity and suppressive mechanisms remain elusive. This review discusses the natural ligands and their potential roles of tumor-specific CD4⁺ regulatory T cells in cancer therapy.

Original language	English (US)
Pages (from-to)	1056-1062
Number of pages	7
Journal	Microbes and Infection
Volume	7
Issue number	7-8
DOIs	https://doi.org/10.1016/j.micinf.2005.03.028
State	Published - Jun 2005

Keywords

Cancer vaccines
CD4 lymphocytes
Foxp3
Immune suppression
Immunotherapy
Regulatory T cells
Tumor immunology

ASJC Scopus subject areas

Microbiology
Infectious Diseases

Access to Document

10.1016/j.micinf.2005.03.028

Cite this

@article{c1fbc10f28694b03902768fae29d55ea,

title = "Antigen-specific CD4+ regulatory T cells in cancer: implications for immunotherapy",

abstract = "Regulatory T cells play essential roles in inducing self-tolerance by suppressing immune responses against self such as autoantigens or non-self-antigens such as tumor and pathogenic antigens. Despite the importance of CD4+ regulatory T cells in many immune-related diseases, their antigen specificity and suppressive mechanisms remain elusive. This review discusses the natural ligands and their potential roles of tumor-specific CD4+ regulatory T cells in cancer therapy.",

keywords = "Cancer vaccines, CD4 lymphocytes, Foxp3, Immune suppression, Immunotherapy, Regulatory T cells, Tumor immunology",

author = "Wang, {Helen Yicheng} and Rongfu Wang",

note = "Funding Information: We apologize to those researchers whose work has not been cited due to space limitations. This work is in part supported by grants from NIH, American Cancer Society and Cancer Research Institute at New York.",

year = "2005",

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T1 - Antigen-specific CD4+ regulatory T cells in cancer

T2 - implications for immunotherapy

AU - Wang, Helen Yicheng

AU - Wang, Rongfu

N1 - Funding Information: We apologize to those researchers whose work has not been cited due to space limitations. This work is in part supported by grants from NIH, American Cancer Society and Cancer Research Institute at New York.

PY - 2005/6

Y1 - 2005/6

N2 - Regulatory T cells play essential roles in inducing self-tolerance by suppressing immune responses against self such as autoantigens or non-self-antigens such as tumor and pathogenic antigens. Despite the importance of CD4+ regulatory T cells in many immune-related diseases, their antigen specificity and suppressive mechanisms remain elusive. This review discusses the natural ligands and their potential roles of tumor-specific CD4+ regulatory T cells in cancer therapy.

AB - Regulatory T cells play essential roles in inducing self-tolerance by suppressing immune responses against self such as autoantigens or non-self-antigens such as tumor and pathogenic antigens. Despite the importance of CD4+ regulatory T cells in many immune-related diseases, their antigen specificity and suppressive mechanisms remain elusive. This review discusses the natural ligands and their potential roles of tumor-specific CD4+ regulatory T cells in cancer therapy.

KW - Cancer vaccines

KW - CD4 lymphocytes

KW - Foxp3

KW - Immune suppression

KW - Immunotherapy

KW - Regulatory T cells

KW - Tumor immunology

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