Antigen-induced regulatory T cells

Stephane Vigouroux, Eric Yvon, Ettore Biagi, Malcolm Brenner

Research output: Contribution to journalReview articlepeer-review

98 Scopus citations


Regulatory T cells participate in immunologic homeostasis by active suppression of inappropriate immune responses. Regulatory T lymphocytes expressing CD4 and CD25 antigens and naturally present in the peripheral blood were the first to be phenotypically characterized. However, their small number and antigen nonspecific suppression has prompted efforts to identify and dissect antigen-specific regulatory T cells. In this review we discuss how antigen-specific regulatory T cells can be identified, the cellular and molecular mechanisms underlying their Induction and activity, and the challenges facing their potential clinical application.

Original languageEnglish (US)
Pages (from-to)26-33
Number of pages8
Issue number1
StatePublished - Jul 1 2004

ASJC Scopus subject areas

  • Biochemistry
  • Immunology
  • Hematology
  • Cell Biology


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