Antielastin autoimmunity in tobacco smoking-induced emphysema

Seung Hyo Lee, Sangeeta Goswami, Ariel Grudo, Li Zhen Song, Venkata Bandi, Sheila Goodnight-White, Linda Green, Joan Hacken-Bitar, Joseph Huh, Faisal Bakaeen, Harvey O. Coxson, Sebastian Cogswell, Claudine Storness-Bliss, David Corry, Farrah Kheradmand

    Research output: Contribution to journalArticlepeer-review

    512 Scopus citations

    Abstract

    Chronic obstructive pulmonary disease and emphysema are common destructive inflammatory diseases that are leading causes of death worldwide. Here we show that emphysema is an autoimmune disease characterized by the presence of antielastin antibody and T-helper type 1 (TH1) responses, which correlate with emphysema severity. These findings link emphysema to adaptive immunity against a specific lung antigen and suggest the potential for autoimmune pathology of other elastin-rich tissues such as the arteries and skin of smokers.

    Original languageEnglish (US)
    Pages (from-to)567-569
    Number of pages3
    JournalNature Medicine
    Volume13
    Issue number5
    DOIs
    StatePublished - May 2007

    ASJC Scopus subject areas

    • General Biochemistry, Genetics and Molecular Biology

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