Antielastin autoimmunity in tobacco smoking-induced emphysema

Seung Hyo Lee; Sangeeta Goswami; Ariel Grudo; Li Zhen Song; Venkata Bandi; Sheila Goodnight-White; Linda Green; Joan Hacken-Bitar; Joseph Huh; Faisal Bakaeen; Harvey O. Coxson; Sebastian Cogswell; Claudine Storness-Bliss; David Corry; Farrah Kheradmand

doi:10.1038/nm1583

Antielastin autoimmunity in tobacco smoking-induced emphysema

Seung Hyo Lee, Sangeeta Goswami, Ariel Grudo, Li Zhen Song, Venkata Bandi, Sheila Goodnight-White, Linda Green, Joan Hacken-Bitar, Joseph Huh, Faisal Bakaeen, Harvey O. Coxson, Sebastian Cogswell, Claudine Storness-Bliss, David Corry, Farrah Kheradmand

Research Institute

Research output: Contribution to journal › Article

423 Scopus citations

Abstract

Chronic obstructive pulmonary disease and emphysema are common destructive inflammatory diseases that are leading causes of death worldwide. Here we show that emphysema is an autoimmune disease characterized by the presence of antielastin antibody and T-helper type 1 (T_H1) responses, which correlate with emphysema severity. These findings link emphysema to adaptive immunity against a specific lung antigen and suggest the potential for autoimmune pathology of other elastin-rich tissues such as the arteries and skin of smokers.

Original language	English (US)
Pages (from-to)	567-569
Number of pages	3
Journal	Nature Medicine
Volume	13
Issue number	5
DOIs	https://doi.org/10.1038/nm1583
State	Published - May 1 2007

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

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10.1038/nm1583

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Antielastin autoimmunity in tobacco smoking-induced emphysema. / Lee, Seung Hyo; Goswami, Sangeeta; Grudo, Ariel; Song, Li Zhen; Bandi, Venkata; Goodnight-White, Sheila; Green, Linda; Hacken-Bitar, Joan; Huh, Joseph; Bakaeen, Faisal; Coxson, Harvey O.; Cogswell, Sebastian; Storness-Bliss, Claudine; Corry, David; Kheradmand, Farrah.

In: Nature Medicine, Vol. 13, No. 5, 01.05.2007, p. 567-569.

Research output: Contribution to journal › Article

Lee, Seung Hyo ; Goswami, Sangeeta ; Grudo, Ariel ; Song, Li Zhen ; Bandi, Venkata ; Goodnight-White, Sheila ; Green, Linda ; Hacken-Bitar, Joan ; Huh, Joseph ; Bakaeen, Faisal ; Coxson, Harvey O. ; Cogswell, Sebastian ; Storness-Bliss, Claudine ; Corry, David ; Kheradmand, Farrah. / Antielastin autoimmunity in tobacco smoking-induced emphysema. In: Nature Medicine. 2007 ; Vol. 13, No. 5. pp. 567-569.

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