@article{9270c780c816499ba925d685fe5018ca,
title = "Antielastin autoimmunity in tobacco smoking-induced emphysema",
abstract = "Chronic obstructive pulmonary disease and emphysema are common destructive inflammatory diseases that are leading causes of death worldwide. Here we show that emphysema is an autoimmune disease characterized by the presence of antielastin antibody and T-helper type 1 (TH1) responses, which correlate with emphysema severity. These findings link emphysema to adaptive immunity against a specific lung antigen and suggest the potential for autoimmune pathology of other elastin-rich tissues such as the arteries and skin of smokers.",
author = "Lee, {Seung Hyo} and Sangeeta Goswami and Ariel Grudo and Song, {Li Zhen} and Venkata Bandi and Sheila Goodnight-White and Linda Green and Joan Hacken-Bitar and Joseph Huh and Faisal Bakaeen and Coxson, {Harvey O.} and Sebastian Cogswell and Claudine Storness-Bliss and David Corry and Farrah Kheradmand",
note = "Funding Information: We thank D. Spencer and B. Zheng for their comments, and R. Wang (Baylor College of Medicine) for providing antibodies to HLA. We thank P. Smithwick, S. Perusich, R. Williams and N. Hanania for their assistance in recruiting subjects. Supported by grants to F.K. and D.B.C. from the US National Institutes of Health and the Alpha 1 Foundation.",
year = "2007",
month = may,
doi = "10.1038/nm1583",
language = "English (US)",
volume = "13",
pages = "567--569",
journal = "Nature Medicine",
issn = "1078-8956",
publisher = "Nature Research",
number = "5",
}