Antielastin autoimmunity in tobacco smoking-induced emphysema

Seung Hyo Lee, Sangeeta Goswami, Ariel Grudo, Li Zhen Song, Venkata Bandi, Sheila Goodnight-White, Linda Green, Joan Hacken-Bitar, Joseph Huh, Faisal Bakaeen, Harvey O. Coxson, Sebastian Cogswell, Claudine Storness-Bliss, David Corry, Farrah Kheradmand

Research output: Contribution to journalArticlepeer-review

429 Scopus citations

Abstract

Chronic obstructive pulmonary disease and emphysema are common destructive inflammatory diseases that are leading causes of death worldwide. Here we show that emphysema is an autoimmune disease characterized by the presence of antielastin antibody and T-helper type 1 (TH1) responses, which correlate with emphysema severity. These findings link emphysema to adaptive immunity against a specific lung antigen and suggest the potential for autoimmune pathology of other elastin-rich tissues such as the arteries and skin of smokers.

Original languageEnglish (US)
Pages (from-to)567-569
Number of pages3
JournalNature Medicine
Volume13
Issue number5
DOIs
StatePublished - May 2007

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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