Anticancer Tc9 cells: Long-lived tumor-killing T cells for adoptive therapy

IL-9-producing cytotoxic T (Tc9) cells represent a unique CD8+ T-cell subset. These long-lived immune cells possess the capacity to acquire effector function and home to tumor tissues after adoptive transfer. IL-9 is indispensable for Tc9-mediated superior antitumor response. These findings are highly significant and crucial to achieve advances in T cell-based adoptive therapies.