Anticancer activity of liposomal bergamot essential oil (BEO) on human neuroblastoma cells

Christian Celia, Elena Trapasso, Marcello Locatelli, Michele Navarra, Cinzia Anna Ventura, Joy Wolfram, Maria Carafa, Valeria Maria Morittu, Domenico Britti, Luisa Di Marzio, Donatella Paolino

Research output: Contribution to journalArticlepeer-review

129 Scopus citations


Citrus extracts, particularly bergamot essential oil (BEO) and its fractions, have been found to exhibit anticancer efficacy. However, the poor water solubility, low stability and limited bioavailability have prevented the use of BEO in cancer therapy. To overcome such drawbacks, we formulated BEO liposomes that improved the water solubility of the phytocomponents and increased their anticancer activity in vitro against human SH-SY5Y neuroblastoma cells. The results warrant further investigation of BEO liposomes for in vivo applications.

Original languageEnglish (US)
Pages (from-to)548-53
Number of pages6
JournalColloids and Surfaces B: Biointerfaces
StatePublished - Dec 1 2013


  • Antineoplastic Agents, Phytogenic
  • Cell Line, Tumor
  • Cell Survival
  • Citrus
  • Drug Delivery Systems
  • Humans
  • Liposomes
  • Methoxsalen
  • Neuroblastoma
  • Oils, Volatile
  • Plant Oils
  • Solubility
  • Journal Article
  • Research Support, Non-U.S. Gov't


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