TY - JOUR
T1 - Antibody Response in Experimental Haemophilus influenzae Otitis Media
AU - Yamaguchi, Tatsuji
AU - Demaria, Thomas F.
AU - Lim, David J.
N1 - Copyright:
Copyright 2015 Elsevier B.V., All rights reserved.
PY - 1986/5
Y1 - 1986/5
N2 - Because Haemophilus influenzae is one of the most common pathogens in otitis media with effusion, we have investigated the antibody response in the serum and middle ear effusion (MEE) in nontypable H influenzae–induced experimental acute otitis media in the chinchilla, using an enzyme-linked immunosorbent assay. During acute otitis media, a reasonable antibody titer was observed: local antibody titers in the MEEs were equal to or greater than those of the serum samples for four of five MEE samples obtained at one week after inoculation. By two weeks, titers in both serum and MEE samples were increased significantly. However, the bacteria persisted in the middle ear cavity, even in the presence of increasing antibody titers, for up to five weeks after infection. The reason for this persistence of the bacteria in the middle ear is unknown. (Arch Otolaryngol Head Neck Surg 1986;112:554-557)
AB - Because Haemophilus influenzae is one of the most common pathogens in otitis media with effusion, we have investigated the antibody response in the serum and middle ear effusion (MEE) in nontypable H influenzae–induced experimental acute otitis media in the chinchilla, using an enzyme-linked immunosorbent assay. During acute otitis media, a reasonable antibody titer was observed: local antibody titers in the MEEs were equal to or greater than those of the serum samples for four of five MEE samples obtained at one week after inoculation. By two weeks, titers in both serum and MEE samples were increased significantly. However, the bacteria persisted in the middle ear cavity, even in the presence of increasing antibody titers, for up to five weeks after infection. The reason for this persistence of the bacteria in the middle ear is unknown. (Arch Otolaryngol Head Neck Surg 1986;112:554-557)
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U2 - 10.1001/archotol.1986.03780050078014
DO - 10.1001/archotol.1986.03780050078014
M3 - Article
C2 - 3513802
AN - SCOPUS:0022497644
SN - 0886-4470
VL - 112
SP - 554
EP - 557
JO - Archives of Otolaryngology--Head and Neck Surgery
JF - Archives of Otolaryngology--Head and Neck Surgery
IS - 5
ER -