Antibodies to L-Type Calcium Channels in Amyotrophic Lateral Sclerosis

A. S. Wierzbicki, W. King Engel, R. Glenn Smith, Enrico Stefani, Stanley H. Appel

Research output: Contribution to journalLetterpeer-review

6 Scopus citations


To the Editor: I was rather confused by the article by Smith et al. (Dec. 10 issue)1 and the related editorial by Rowland2. The authors suggest that high-titer antibodies to human motor-neuron voltage-gated calcium channels (VGCCs) present in patients with amyotrophic lateral sclerosis (ALS) cross-react with rabbit L-type VGCC epitopes. Skeletal-muscle L-type channels show only 15 to 45 percent homology with extracellular domains of neuronal L-type channels, and thus high titers are more likely to suggest a reaction to a primary muscle antigen3. The assay used for L-type VGCCs is novel in that it relies on a sandwich…

Original languageEnglish (US)
Pages (from-to)1355-1357
Number of pages3
JournalNew England Journal of Medicine
Issue number18
StatePublished - May 6 1993

ASJC Scopus subject areas

  • Medicine(all)


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