Antibiotic therapy in preterm premature rupture of membranes: Are seven days necessary? A preliminary, randomized clinical trial

David F. Lewis, C. David Adair, Alfred G. Robichaux, Ronald K. Jaekle, Jodi A. Moore, Arthur T. Evans, M. Todd Fontenot, Brian M. Mercer, Karolina Adam, Mara J. Dinsmoor, Robert Mittendorf

Research output: Contribution to journalArticle

31 Scopus citations

Abstract

OBJECTIVE: The purpose of this study was to determine whether 3 days of broad-spectrum antibiotic therapy, which is intended to prolong latency in patients with preterm premature rupture of membranes, is comparable to 7 days of therapy. STUDY DESIGN: Patients with preterm premature rupture of membranes at three separate study sites were asked to participate in this intent-to-treat, prospective, randomized trial. They were assigned randomly to either 3 or 7 days of ampicillin-sulbactam (3 g intravenously every 6 hours). The primary outcome of interest was the latency period from membrane rupture to delivery. RESULTS: Forty-two individuals were enrolled in each group. No difference was noted in the latency interval between the two groups (3 days, 214 ± 225 hours, vs 7 days, 229 ± 218 hours). A significantly higher number of patients in the 3-day group completed therapy (80.1% vs 47.6%, P = .003). No other parameters were significantly different between the two groups. No adverse events or trends were noted in either group. CONCLUSION: There appears to be no difference in the latency period between 3 and 7 days of ampicillin-sulbactam antibiotic therapy. More patients are needed to exclude a type II error.

Original languageEnglish (US)
Pages (from-to)1413-1417
Number of pages5
JournalAmerican Journal of Obstetrics and Gynecology
Volume188
Issue number6
DOIs
StatePublished - Jun 1 2003

Keywords

  • Latency period
  • Preterm premature rupture of membranes

ASJC Scopus subject areas

  • Medicine(all)
  • Obstetrics and Gynecology

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