TY - JOUR
T1 - Antiarrhythmic efficacy of ethmozine® (moricizine HCl) compared with disopyramide and propranolol
AU - Pratt, Craig
AU - Butman, Samuel M.
AU - Young, James B.
AU - Knoll, Margaret
AU - English, La Dean
PY - 1987/10/16
Y1 - 1987/10/16
N2 - In the investigation of new antiarrhythmic drugs, comparative trials with clinically available antiarrhythmic agents provide a perspective from which to judge the new investigational agent. Two clinical investigations of moricizine HCl, each using a placebo-controlled, double-blind, crossover design, are summarized. In the first study, 18 patients with ≥ 30 ventricular premature complexes (VPCs) per hour (mean 369 ± 95) were given propranolol (120 mg daily) compared with moricizine HCl (816 ± 103 mg daily). Propranolol suppressed 38% of VPCs in the study group, moricizine HCl, 81% of VPCs, and the combination of both drugs, 87%. Moricizine HCl was more effective than propranolol in suppressing VPCs at all individual levels > 70% (p < 0.05, McNemar's test). The combination of moricizine HCl and propranolol was well tolerated. The second investigation used a placebo-controlled, double-blind, crossover design to compare the efficacy of disopyramide (600 mg daily) and moricizine HCl (800 mg daily) in 27 patients. Patients had ≥ 40 VPCs/hr on a 24-hour ambulatory electrocardiogram. During moricizine HCl administration, the mean VPC frequency decreased from 524 to 151 VPCs/hr (71.2% reduction). In contrast, disopyramide reduced VPC frequency from 535 to 253 VPCs/hr (52.8% reduction) and demonstrated significantly greater side effects (p < 0.05). Moricizine HCl was more effective than disopyramide in suppressing VPCs at all individual percent reduction levels >70% (p < 0.05, McNemar's test). Moricizine HCl was more effective in suppressing VPCs than either disopyramide or propranolol, with significantly fewer side effects.
AB - In the investigation of new antiarrhythmic drugs, comparative trials with clinically available antiarrhythmic agents provide a perspective from which to judge the new investigational agent. Two clinical investigations of moricizine HCl, each using a placebo-controlled, double-blind, crossover design, are summarized. In the first study, 18 patients with ≥ 30 ventricular premature complexes (VPCs) per hour (mean 369 ± 95) were given propranolol (120 mg daily) compared with moricizine HCl (816 ± 103 mg daily). Propranolol suppressed 38% of VPCs in the study group, moricizine HCl, 81% of VPCs, and the combination of both drugs, 87%. Moricizine HCl was more effective than propranolol in suppressing VPCs at all individual levels > 70% (p < 0.05, McNemar's test). The combination of moricizine HCl and propranolol was well tolerated. The second investigation used a placebo-controlled, double-blind, crossover design to compare the efficacy of disopyramide (600 mg daily) and moricizine HCl (800 mg daily) in 27 patients. Patients had ≥ 40 VPCs/hr on a 24-hour ambulatory electrocardiogram. During moricizine HCl administration, the mean VPC frequency decreased from 524 to 151 VPCs/hr (71.2% reduction). In contrast, disopyramide reduced VPC frequency from 535 to 253 VPCs/hr (52.8% reduction) and demonstrated significantly greater side effects (p < 0.05). Moricizine HCl was more effective than disopyramide in suppressing VPCs at all individual percent reduction levels >70% (p < 0.05, McNemar's test). Moricizine HCl was more effective in suppressing VPCs than either disopyramide or propranolol, with significantly fewer side effects.
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U2 - 10.1016/0002-9149(87)90722-3
DO - 10.1016/0002-9149(87)90722-3
M3 - Article
C2 - 3310586
AN - SCOPUS:0023634697
VL - 60
SP - 52
EP - 58
JO - American Journal of Cardiology
JF - American Journal of Cardiology
SN - 0002-9149
IS - 11
ER -