Anti-diarrhoeal potential of asparagus racemosus wild root extracts in laboratory animals

N. Venkatesan, Vadivu Thiyagarajan, Sathiya Narayanan, Arokya Arul, Sundararajan Raja, Sengodan Gurusamy Vijaya Kumar, Rajarajan Amirthalingam Thandavarayan, James Britto Perianayagam

Research output: Contribution to journalArticle

101 Scopus citations

Abstract

Purpose: Asparagus racemosus Wild root has been used traditionally in Ayurveda for the treatment of diarrhoea and dysentery. However, the claims of Ayurveda need to be validated by a suitable experimental model. Therefore, the present study was under-taken to evaluate the effect of ethanol and aqueous extracts of Asparagus racemosus for its antidiarrhoeal potential against several experimental models of diarrhoea in Albino Wistar rats. Methods: The antidiarrhoeal activity of ethanol and aqueous extracts of Asparagus racemosus root was evaluated using castor oil-induced diarrhoea model in rats. Further, we evaluated the effect of ethanol and aqeous extracts on gastrointestinal tract motility after charcoal meal administration and PGE2 induced intestinal fluid accumulation (enteropooling). Loperamide was used as positive control. Results: The plant extracts showed significant (P 〈 0.05) inhibitor activity against castor oil induced diarrhoea and PGE2 induced enteropooling in rats when tested at 200 mg/kg. Both extracts also showed significant (P 〈 0.001) reduction in gastrointestinal motility in charcoal meal test in rats. Conclusion: The results point out the possible anti-diarrhoeal effect of the plant extracts and substantiate the use of this herbal remedy as a non-specific treatment for diarrhoea in folk medicine.

Original languageEnglish (US)
Pages (from-to)39-45
Number of pages7
JournalJournal of Pharmacy and Pharmaceutical Sciences
Volume8
Issue number1
StatePublished - Jan 1 2005

ASJC Scopus subject areas

  • Pharmacology
  • Pharmaceutical Science

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