TY - JOUR
T1 - Anti-atherogenic effects of morelloflavone from Garcinia dulcis leaves in cholesterol fed rabbits
AU - Decha-Dier, Usawadee
AU - Hutadilok-Towatana, Nongporn
AU - Mahabusarakam, Wilawan
AU - Sawangjaroen, Kitja
AU - Pinkaew, Decha
PY - 2008/7
Y1 - 2008/7
N2 - A biflavonoid, morelloflavone isolated from leaves of Garcinia dulcis Kurz was investigated for its ability to reduce plasma lipids and prevent progression of atherosclerotic lesions in hypercholesterolemic rabbits. Male rabbits were divided into 6 groups. Group 1 received a regular diet, Group 2 received a regular diet with 0.02% (w/w) of G. dulcis derived morelloflavone, Group 3 was fed a diet containing 1% (w/ w) cholesterol to induce hypercholesterolemia, and Group 4 to Group 6 had their 1% cholesterol diets supplemented with morelloflavone at concentrations of 0.005%, 0.01% and 0.02%, respectively. During a 4 month-experimental period, rabbits were monitored for their body weights and plasma cholesterol, triglycerides and thiobarbituric acid-reactive substances (TBARS) levels monthly and the extent of aortic atherosclerotic lesions were analysed at the end of the period. The levels of plasma cholesterol, triglycerides and TBARS as well as intimal thickening within aortas were increased in all animals fed with cholesterol diets. Such increases, however, were reduced in the presence of morelloflavone. The concentrations of morelloflavone that showed inhibitory effects in all cases were 0.005% and 0.0 1%, whereas the 0.02% dosage was ineffective.
AB - A biflavonoid, morelloflavone isolated from leaves of Garcinia dulcis Kurz was investigated for its ability to reduce plasma lipids and prevent progression of atherosclerotic lesions in hypercholesterolemic rabbits. Male rabbits were divided into 6 groups. Group 1 received a regular diet, Group 2 received a regular diet with 0.02% (w/w) of G. dulcis derived morelloflavone, Group 3 was fed a diet containing 1% (w/ w) cholesterol to induce hypercholesterolemia, and Group 4 to Group 6 had their 1% cholesterol diets supplemented with morelloflavone at concentrations of 0.005%, 0.01% and 0.02%, respectively. During a 4 month-experimental period, rabbits were monitored for their body weights and plasma cholesterol, triglycerides and thiobarbituric acid-reactive substances (TBARS) levels monthly and the extent of aortic atherosclerotic lesions were analysed at the end of the period. The levels of plasma cholesterol, triglycerides and TBARS as well as intimal thickening within aortas were increased in all animals fed with cholesterol diets. Such increases, however, were reduced in the presence of morelloflavone. The concentrations of morelloflavone that showed inhibitory effects in all cases were 0.005% and 0.0 1%, whereas the 0.02% dosage was ineffective.
KW - Atherosclerosis
KW - Atherosclerotic lesion
KW - Garcinia dulcis
KW - Hypercholesterolemic rabbit
KW - Hypolipidemic effect
KW - Morelloflavone
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M3 - Article
AN - SCOPUS:51649117644
VL - 8
SP - 151
EP - 159
JO - Journal of Natural Remedies
JF - Journal of Natural Remedies
SN - 0972-5547
IS - 2
ER -