Anthelmintic and antimicrobial properties of peels of Citrus sinensis

A. T. Rajarajan, V. G. Vijayasree, Watanabe Kenichi, S. Vijaya Kumar, G. Narasimman, S. Sadish Kumar

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


The objective of the present investigation was to determine the anthelmintic and antimicrobial activity of petroleum ether extract of the peels of Citrus sinensis. Anthelmintic activity of this extract was evaluated on Indian adult earthworms, Pheretima posthuma, and exhibited a dose dependent inhibition of spontaneous motility (paralysis), and evoked responses to pin-prick, and the effects were comparable with that of piperazine citrate. The extract were also assayed for antimicrobial activity against various Gram positive organisms such as Staphylococcus epidermidis, Micrococcus luteus, Bacillus subtilis, and Gram negative organisms such as Escherichia coli, Pseudomonas vulgaris, Salmonella typhi, and fungal strains Aspergillus niger, and Candida albicans. Antimicrobial activity was conducted by the agar well diffusion method. The extract showed varies levels of antimicrobial activity on different test microorganisms. Future studies are in process to isolate the active principles responsible for the activity.

Original languageEnglish (US)
Pages (from-to)363-368
Number of pages6
StatePublished - 2009


  • Anthelmintic activity
  • Antimicrobial activity
  • Citrus sinensis (Rutaceae)
  • Peels
  • Petroleum ether extract

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery


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