Anterior Segment Optical Coherence Tomography of Ocular Cystinosis Confirmed by Electron Microscopy

Abhinav Golla, Mitchell P. Weikert, Patricia Chevez-Barrios, Zaina Al-Mohtaseb

Research output: Contribution to journalArticle

Abstract

Purpose: To report a case of ocular cystinosis diagnosed by anterior segment optical coherence tomography (AS-OCT) and histopathology. Methods: A 67-year-old man who presented with eye pain was found to have unilateral corneal crystal deposition. Ocular cystinosis was diagnosed by histopathology, AS-OCT, and lack of renal involvement of the disease. Results: AS-OCT showed hyperreflective densities in the corneal epithelium. The patient underwent superficial keratectomy given irregular astigmatism prior to cataract surgery. Electron microscopy of the corneal scrapings revealed epithelial cells with intracystoplasmic membrane-bound crystals confirming the diagnosis of cystinosis. Conclusion: To our knowledge, this is the first reported case of ocular cystinosis involving strictly the epithelial layer of the cornea that has been imaged by AS-OCT.

Original languageEnglish (US)
Pages (from-to)110-113
Number of pages4
JournalOcular Oncology and Pathology
Volume5
Issue number2
DOIs
StatePublished - Feb 1 2019

Keywords

  • Anterior segment optical coherence tomography
  • Electron microscopy
  • Ocular cystinosis

ASJC Scopus subject areas

  • Nursing(all)

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