A previously unknown oestrogen receptor, ERβ, has recently been isolated. ERβ is expressed in many important target tissues for oestrogen (ie, prostate, ovary, testis, and the cardiovascular and central nervous systems), and probably mediates many of the effects of oestrogens in the human body. Moreover, ERβ represents an interesting target for drug development, and ligands specific for the respective receptor subtype may offer interesting possibilities for the treatment of postmenopausal symptoms, and breast and prostate cancer, without many of the hitherto adverse side effects, such as the increased risk of endometrial cancer associated with hormone replacement therapy.
|Translated title of the contribution||Another oestrogen receptor discovered; New treatment options for postmenopausal symptoms, osteoporosis, atherosclerosis, and breast and prostate cancer may be possible|
|Number of pages||5|
|State||Published - Dec 1 1998|
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