Animal models of ABPA provide an intriguing insight into disease pathogenesis across various species. In the mouse, the availability of gene-targeted animals allows for a detailed dissection of critical cells and cytokines that mediate immunopathology. T cells are the central effectors that ultimately induce lung pathology and airway hyperreactivity in murine ABPA.
ASJC Scopus subject areas
- Immunology and Allergy