Animal models in brain–computer interface research

Yu Tung Lo; Lei Jiang; Jordan L.W. Lam; Ben Woodington; Elise P.W. Jenkins; Vasileios Christopoulos; Darrin J. Lee; Yuxin Liu; Charles Y. Liu

doi:10.1038/s44222-025-00313-6

Animal models in brain–computer interface research

Yu Tung Lo, Lei Jiang, Jordan L.W. Lam, Ben Woodington, Elise P.W. Jenkins, Vasileios Christopoulos, Darrin J. Lee, Yuxin Liu, Charles Y. Liu

Research output: Contribution to journal › Comment/debate › peer-review

1 Scopus citations

Abstract

The development of chronic implantable brain–computer interface devices requires extensive preclinical testing, for which various animal models can be used. However, bridging the translational gap requires strategic consideration of their brains’ physiological, anatomical and functional organization differences.

Original language	English (US)
Pages (from-to)	623-625
Number of pages	3
Journal	Nature Reviews Bioengineering
Volume	3
Issue number	8
DOIs	https://doi.org/10.1038/s44222-025-00313-6
State	Published - Aug 2025

ASJC Scopus subject areas

Biophysics
Biomedical Engineering
Applied Microbiology and Biotechnology

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10.1038/s44222-025-00313-6

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title = "Animal models in brain–computer interface research",

abstract = "The development of chronic implantable brain–computer interface devices requires extensive preclinical testing, for which various animal models can be used. However, bridging the translational gap requires strategic consideration of their brains{\textquoteright} physiological, anatomical and functional organization differences.",

author = "Lo, \{Yu Tung\} and Lei Jiang and Lam, \{Jordan L.W.\} and Ben Woodington and Jenkins, \{Elise P.W.\} and Vasileios Christopoulos and Lee, \{Darrin J.\} and Yuxin Liu and Liu, \{Charles Y.\}",

note = "Publisher Copyright: {\textcopyright} Springer Nature Limited 2025.",

year = "2025",

month = aug,

doi = "10.1038/s44222-025-00313-6",

language = "English (US)",

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AU - Lo, Yu Tung

AU - Jiang, Lei

AU - Lam, Jordan L.W.

AU - Woodington, Ben

AU - Jenkins, Elise P.W.

AU - Christopoulos, Vasileios

AU - Lee, Darrin J.

AU - Liu, Yuxin

AU - Liu, Charles Y.

PY - 2025/8

Y1 - 2025/8

N2 - The development of chronic implantable brain–computer interface devices requires extensive preclinical testing, for which various animal models can be used. However, bridging the translational gap requires strategic consideration of their brains’ physiological, anatomical and functional organization differences.

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VL - 3

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JO - Nature Reviews Bioengineering

JF - Nature Reviews Bioengineering

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ER -

Animal models in brain–computer interface research

Abstract

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