TY - JOUR
T1 - Angiotensin-converting enzyme 2 as a therapeutic target for heart failure
AU - Chamsi-Pasha, Mohammed A.R.
AU - Shao, Zhili
AU - Tang, W. H.Wilson
N1 - Funding Information:
W.H.W. Wilson Tang is supported by National Institutes of Health grants R01HL103931 and P20HL113452, as well as grants from FoldRx Pharmaceuticals, Inc./Pfizer, Respicardia, Inc., and St. Jude Medical, Inc.; has received compensation from Medtronic, Inc., and St. Jude Medical, Inc. for service as a consultant.
PY - 2014/3
Y1 - 2014/3
N2 - The renin-angiotensin system (RAS) plays a major role in the pathophysiology of cardiovascular disorders. Angiotensin II (Ang-II), the final product of this pathway, is known for its vasoconstrictive and proliferative effects. Angiotensin-converting enzyme 2 (ACE2), a newly discovered homolog of ACE, plays a key role as the central negative regulator of the RAS. It diverts the generation of vasoactive Ang-II into the vasodilatory and growth inhibiting peptide angiotensin(1-7) [Ang(1-7)], thereby providing counter-regulatory responses to neurohormonal activation. There is substantial experimental evidence evaluating the role of ACE2/Ang(1-7) in hypertension, heart failure, and atherosclerosis. In this review, we aim to focus on the conceptual facts of the ACE2-Ang(1-7) axis with regards to clinical implications and therapeutic targets in cardiovascular disorders, with emphasis on the potential therapeutic role in cardiovascular diseases.
AB - The renin-angiotensin system (RAS) plays a major role in the pathophysiology of cardiovascular disorders. Angiotensin II (Ang-II), the final product of this pathway, is known for its vasoconstrictive and proliferative effects. Angiotensin-converting enzyme 2 (ACE2), a newly discovered homolog of ACE, plays a key role as the central negative regulator of the RAS. It diverts the generation of vasoactive Ang-II into the vasodilatory and growth inhibiting peptide angiotensin(1-7) [Ang(1-7)], thereby providing counter-regulatory responses to neurohormonal activation. There is substantial experimental evidence evaluating the role of ACE2/Ang(1-7) in hypertension, heart failure, and atherosclerosis. In this review, we aim to focus on the conceptual facts of the ACE2-Ang(1-7) axis with regards to clinical implications and therapeutic targets in cardiovascular disorders, with emphasis on the potential therapeutic role in cardiovascular diseases.
KW - Angiotensin (1-7)
KW - Angiotensin converting enzyme 2
KW - Heart failure
KW - Renin angiotensin system
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U2 - 10.1007/s11897-013-0178-0
DO - 10.1007/s11897-013-0178-0
M3 - Article
C2 - 24293035
AN - SCOPUS:84896730319
SN - 1546-9530
VL - 11
SP - 58
EP - 63
JO - Current heart failure reports
JF - Current heart failure reports
IS - 1
ER -