Angiosarcoma at unusual sites

Seema Mullick, Dina R. Mody, Mary R. Schwartz

Research output: Contribution to journalArticlepeer-review

26 Scopus citations


BACKGROUND: Angiosarcomas are uncommon soft tissue neoplasms with a predilection for skin and superficial soft tissues. CASES: Two cases of angiosarcoma occurred at unusual sites, the parotid gland and lung. The parotid lesion was characterized by malignant cells present singly, in loose groups, in tight three-dimensional aggregates and in acinar formation initially misinterpreted as an adenocarcinoma. The lung mass showed malignant cells in association with vascular endothelium, suggestive of angiosarcoma. Both cases were negative for Ulex europaeus and Factor VIII-related protein but demonstrated strong immunopositivity for CD31, a highly specific endothelial marker. CONCLUSION: In the absence of vasoformative structures important diagnostic pitfalls are pseudovascular adenoid squamous cell carcinoma, poorly differentiated adenocarcinoma, melanoma and lymphoma. Immunocytochemical studies and clinical history are essential to the correct diagnosis.

Original languageEnglish (US)
Pages (from-to)839-844
Number of pages6
JournalActa Cytologica
Issue number3
StatePublished - 1997


  • angiosarcoma
  • aspiration biopsy

ASJC Scopus subject areas

  • Anatomy
  • Cell Biology
  • Histology


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