Angiomyofibroblastoma: A clinicopathologic study of eight cases and review of the literature

Mariela D. Vasquez, Jae Ro, Yong W. Park, Carmen S. Tornos, Nelson G. Ordoñez, Alberto Ayala

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10 Scopus citations


We report the clinicopathologic features of eight new cases of angiomyofibroblastoma and review the literature on this recently described entity. Most of our female patients had a vulvar mass that clinically was thought to be a Bartholin's gland cyst. The tumors were well circumscribed and measured 2.9 to 11 cm (mean, 5.2 cm). No recurrences or metastases were observed during follow-up, which ranged from 2 months to 4 years. The tumors were characterized by a myxomatous background with prominent vessels surrounded by plump stromal cells. Immunohistochemically, the stromal cells were reactive for vimentin, but staining for desmin was not always present. Angiomyofibroblastoma should be distinguished from aggressive angiomyxoma because the two entities behave differently. Morphologic and immunohistochemical features should also be considered.

Original languageEnglish (US)
Pages (from-to)161-169
Number of pages9
JournalInternational Journal of Surgical Pathology
Issue number3
StatePublished - Jan 1 1999


  • Aggressive angiomyxoma
  • Angiomyofibroblastoma
  • Vulva

ASJC Scopus subject areas

  • Anatomy
  • Pathology and Forensic Medicine
  • Surgery


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