Angioimmunoblastic lymphadenopathy with hypogammaglobulinemia. Possible role of monocyte suppression

Lawrence Rice, Stuart L. Abramson, Arline H. Laughter, Thomas M. Wheeler, Jeremiah J. Twomey

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

A patient with angioimmunoblastic lymphadenopathy had low serum immunoglobulin values and no antibodies to injected immunogens. This occurred despite the proliferation of polyclonal B cells. T cells were deficient in number and in lymphoproliferative responses, but their helper and suppressor functions were maintained, la-antigen bearing leukocytes from the patient stimulated poorly in mixed leukocyte culture. In vitro immunoglobulin synthesis by mononuclear leukocytes from the patient was severely impaired. These leukocytes actively suppressed immunoglobulin synthesis by normal cells from healthy subjects in co-culture. The responsible cell had characteristics of a monocyte. The suppression was selective for humoral immunity and was manifest despite normal numbers of monocytes. It appears that heterogeneous immunoregulatory abnormalities can underlie the syndrome of angioimmunoblastic lymphadenopathy. Furthermore, monocyte suppressor abnormalities may be implicated in clinical disease phenomena.

Original languageEnglish (US)
Pages (from-to)998-1004
Number of pages7
JournalThe American journal of medicine
Volume72
Issue number6
DOIs
StatePublished - Jun 1982

ASJC Scopus subject areas

  • Medicine(all)

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