Angiographic evaluation of the interventricular septum in early reperfusion

Rene A. Langou, H. Dirk Sostman, Steven Wolfson, Allen L. Simon

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Septal motion was studied by left ventricular angiography in acute myocardial ischemia (MI) and reperfusion (R) in 7 dogs. This group was compared to an ischemic group without reperfusion (NR). An initial left ventriculogram in the 80° left anterior oblique projection was performed. Then the left anterior descending artery was ligated. Seven dogs were allocated to the reperfusion group and equal number to the non reperfusion group. In the reperfusion group a second ventriculogram was performed 60 min post ligature of the left anterior descending artery (MI). Immediately thereafter, the left anterior descending artery ligature was released; 60 min after release (120 min after ligature), a third ventriculogram was done (R). In the non reperfusion group the same protocol was carried out, except that the ligature of the left anterior descending artery was retained. An axis was drawn between the mid aortic valve plane and the apex of the left ventricle. Axis to septal distances in end diastole (D) and end systole (S) were measured at 3 equidistant points along this axis, and their ratios compared (D/S). Thus an increase in septal hemiaxis ratios (D/S ratios) indicates an improvement in septal motion. Septal motion ratios fell after myocardial ischemia in both reperfused and non reperfused groups (p < 0.05). After reperfusion, small but significant (paired T test) further decreases were observed in the mid and distal septal segments (p < 0.05) and for middle septal segment (p 0.01). We conclude that early reperfusion results in worsening of septal motion as assessed angiographically.

Original languageEnglish (US)
Pages (from-to)314-318
Number of pages5
JournalInvestigative Radiology
Issue number4
StatePublished - 1977


  • Coronary ligation
  • Myocardial ischemia
  • Reperfusion
  • Septal motion

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


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