Androgens promote prostate cancer cell growth through induction of autophagy

Yan Shi, Jenny J. Han, Jayantha B. Tennakoon, Fabiola F. Mehta, Fatima A. Merchant, Alan R. Burns, Matthew K. Howe, Donald P. McDonnell, Daniel E. Frigo

Research output: Contribution to journalArticle

54 Scopus citations

Abstract

Androgens regulate both the physiological development of the prostate and the pathology of prostatic diseases. However, the mechanisms by which androgens exert their regulatory activities on these processes are poorly understood. In this study, we have determined that androgens regulate overall cell metabolism and cell growth, in part, by increasing autophagy in prostate cancer cells. Importantly, inhibition of autophagy using either pharmacological or molecular inhibitors significantly abrogated androgen-induced prostate cancer cell growth. Mechanistically, androgen-mediated autophagy appears to promote cell growth by augmenting intracellular lipid accumulation, an effect previously demonstrated to be necessary for prostate cancer cell growth. Further, autophagy and subsequent cell growth is potentiated, in part, by androgen-mediated increases in reactive oxygen species. These findings demonstrate a role for increased fat metabolism and autophagy in prostatic neoplasias and highlight the potential of targeting underexplored metabolic pathways for the development of novel therapeutics.

Original languageEnglish (US)
Pages (from-to)280-295
Number of pages16
JournalMolecular Endocrinology
Volume27
Issue number2
DOIs
StatePublished - Feb 2013

ASJC Scopus subject areas

  • Molecular Biology
  • Endocrinology

Fingerprint Dive into the research topics of 'Androgens promote prostate cancer cell growth through induction of autophagy'. Together they form a unique fingerprint.

Cite this