Androgen responsiveness of the liver of the developing rat

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Abstract

The activities of the hepatic microsomal 2α, 2β, 7α and 18 hydroxylase systems active on 5α [4 14C]androstane 3α,17β diol were studied in male and female rats which had been castrated at birth and at the age of 7, 13, 21, 27, 34, 43 and 55 days, treated for 5 days with 2 mg of testosterone propionate/kg body weight and killed 6 days after castration. The 7α hydroxylase system was affected very little by androgen treatment at all stages during development. On the other hand it was found that the rat liver passed through 3 phases during development with respect to androgen responsiveness as judges by changes in the activities of the 2α, 2β and 18 hydroxylase systems: a first phase (from the neonatal period up to about 19 days of age) with a relative androgen unresponsiveness in both male and female rats, a second phase (from about 27 to about 33 days of age) when male and female rats responded equally well to androgens and a final phase (from about 40 days of age) with a successively decreasing androgen responsiveness in female rats but with a retained responsiveness in male rats. The hypothesis is presented that neonatal imprinting of the liver by testicular androgen(s) determines the development and degree of androgen responsiveness of liver tissue in the rat.

Original languageEnglish (US)
Pages (from-to)225-229
Number of pages5
JournalBiochemical Journal
Volume144
Issue number2
DOIs
StatePublished - 1974

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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