Androgen Receptor-Related Non-coding RNAs in Prostate Cancer

Yongyong Yang, Kilia Y. Liu, Qi Liu, Qi Cao

Research output: Contribution to journalReview article

Abstract

Prostate cancer (PCa) is the second leading cause of cancer-related death among men in the United States. Androgen receptor (AR) signaling is the dominant oncogenic pathway in PCa and the main strategy of PCa treatment is to control the AR activity. A large number of patients acquire resistance to Androgen deprivation therapy (ADT) due to AR aberrant activation, resulting in castration-resistant prostate cancer (CRPC). Understanding the molecular mechanisms underlying AR signaling in the PCa is critical to identify new therapeutic targets for PCa patients. The recent advances in high-throughput RNA sequencing (RNA-seq) techniques identified an increasing number of non-coding RNAs (ncRNAs) that play critical roles through various mechanisms in different diseases. Some ncRNAs have shown great potentials as biomarkers and therapeutic targets. Many ncRNAs have been investigated to regulate PCa through direct association with AR. In this review, we aim to comprehensively summarize recent findings of the functional roles and molecular mechanisms of AR-related ncRNAs as AR regulators or targets in the progression of PCa.

Original languageEnglish (US)
Article number660853
JournalFrontiers in Cell and Developmental Biology
Volume9
DOIs
StatePublished - Apr 1 2021

Keywords

  • androgen receptor
  • circRNA
  • lncRNA
  • microRNA
  • non-coding RNA
  • prostate cancer

ASJC Scopus subject areas

  • Developmental Biology
  • Cell Biology

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