Androgen receptor agonism promotes an osteogenic gene program in preadipocytes

Sean M. Hartig, Qin Feng, Scott A. Ochsner, Rui Xiao, Neil J. McKenna, Sean E. McGuire, Bin He

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

Androgens regulate body composition by interacting with the androgen receptor (AR) to control gene expression in a tissue-specific manner. To identify novel regulatory roles for AR in preadipocytes, we created a 3T3-L1 cell line stably expressing human AR. We found AR expression is required for androgen-mediated inhibition of 3T3-L1 adipogenesis. This inhibition is characterized by decreased lipid accumulation, reduced expression of adipogenic genes, and induction of genes associated with osteoblast differentiation. Collectively, our results suggest androgens promote an osteogenic gene program at the expense of adipocyte differentiation.

Original languageEnglish (US)
Pages (from-to)357-362
Number of pages6
JournalBiochemical and Biophysical Research Communications
Volume434
Issue number2
DOIs
StatePublished - May 3 2013

Keywords

  • Adipocyte
  • Androgen receptor
  • Gene regulation
  • Osteoblast

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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