The metabolism in vitro of 4 androgens, namely testosterone, androstenedione, 5α-dihydrotestosterone and 3α-androstanediol has been studied in male and female rat anterior pituitary cells in primary culture. When testosterone was used as precursor, androstenedione, 5α-dihydrotestosterone and 3α-androstanediol were the main metabolites whereas androstenedione was mainly converted into testosterone, 5α-androstanedione, 5α-dihydrotestosterone and androsterone. Studies on the metabolism of 5α-dihydrotestosterone and 3α-androstanediol showed that these compounds were easily interconverted and were also significantly metabolized to 5α-androstanedione and androsterone. No aromatized compounds could be detected suggesting that androgen action in the pituitary cell occurs directly via the androgen receptor rather than through prior conversion into estrogens.
- 3α-Adiol, (3α,17β-dihydroxy-5α-androstane)
- 3α-Adiol, (3α,17β-dihydroxy-5α-androstane), androst-4-ene-3,17-dione)
- 3β-Adiol (3β,17β-dihydroxy-5αx-androstane)
- DHT (17β-hydroxy-5α-androstan-3-one)
ASJC Scopus subject areas
- Molecular Biology