Androgen metabolism in rat anterior pituitary cells in culture

A. Belanger, Lena Lundell, P. Eneroth, J. A. Gustafsson

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

The metabolism in vitro of 4 androgens, namely testosterone, androstenedione, 5α-dihydrotestosterone and 3α-androstanediol has been studied in male and female rat anterior pituitary cells in primary culture. When testosterone was used as precursor, androstenedione, 5α-dihydrotestosterone and 3α-androstanediol were the main metabolites whereas androstenedione was mainly converted into testosterone, 5α-androstanedione, 5α-dihydrotestosterone and androsterone. Studies on the metabolism of 5α-dihydrotestosterone and 3α-androstanediol showed that these compounds were easily interconverted and were also significantly metabolized to 5α-androstanedione and androsterone. No aromatized compounds could be detected suggesting that androgen action in the pituitary cell occurs directly via the androgen receptor rather than through prior conversion into estrogens.

Original languageEnglish (US)
Pages (from-to)175-181
Number of pages7
JournalMolecular and cellular endocrinology
Volume19
Issue number2
DOIs
StatePublished - 1980

Keywords

  • 17β-dehydrogenase
  • 3α-Adiol, (3α,17β-dihydroxy-5α-androstane)
  • 3α-Adiol, (3α,17β-dihydroxy-5α-androstane), androst-4-ene-3,17-dione)
  • 3α-androstanediol
  • 3α-androstanediol
  • 3α-dehydrogenase
  • 3β-Adiol (3β,17β-dihydroxy-5αx-androstane)
  • 3β-androstanediol
  • 3β-dehydrogenase
  • 5α-dihydrotestosterone
  • 5α-reductase
  • DHT (17β-hydroxy-5α-androstan-3-one)
  • T,(17β-hydroxy-androst-4-en-3-one)
  • androgen
  • androst-4-ene-3-,17-dione)
  • androstenedione
  • metabolism
  • pituitary
  • testosterone

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Endocrinology

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