And yet it moves: Recovery of volitional control after spinal cord injury

G. Taccola, D. Sayenko, P. Gad, Y. Gerasimenko, V. R. Edgerton

Research output: Contribution to journalReview article

49 Scopus citations

Abstract

Preclinical and clinical neurophysiological and neurorehabilitation research has generated rather surprising levels of recovery of volitional sensory-motor function in persons with chronic motor paralysis following a spinal cord injury. The key factor in this recovery is largely activity-dependent plasticity of spinal and supraspinal networks. This key factor can be triggered by neuromodulation of these networks with electrical and pharmacological interventions. This review addresses some of the systems-level physiological mechanisms that might explain the effects of electrical modulation and how repetitive training facilitates the recovery of volitional motor control. In particular, we substantiate the hypotheses that: (1) in the majority of spinal lesions, a critical number and type of neurons in the region of the injury survive, but cannot conduct action potentials, and thus are electrically non-responsive; (2) these neuronal networks within the lesioned area can be neuromodulated to a transformed state of electrical competency; (3) these two factors enable the potential for extensive activity-dependent reorganization of neuronal networks in the spinal cord and brain, and (4) propriospinal networks play a critical role in driving this activity-dependent reorganization after injury. Real-time proprioceptive input to spinal networks provides the template for reorganization of spinal networks that play a leading role in the level of coordination of motor pools required to perform a given functional task. Repetitive exposure of multi-segmental sensory-motor networks to the dynamics of task-specific sensory input as occurs with repetitive training can functionally reshape spinal and supraspinal connectivity thus re-enabling one to perform complex motor tasks, even years post injury.

Original languageEnglish (US)
Pages (from-to)64-81
Number of pages18
JournalProgress in Neurobiology
Volume160
DOIs
StatePublished - Jan 1 2018

Keywords

  • Electrical stimulation
  • Motor training
  • Neuromodulation
  • Spinal networks

ASJC Scopus subject areas

  • Neuroscience(all)

Fingerprint Dive into the research topics of 'And yet it moves: Recovery of volitional control after spinal cord injury'. Together they form a unique fingerprint.

Cite this