BACKGROUND: The optimal extent of resection for a patient with a typical carcinoid tumor has been controversial. Studies suggest that wedge resection is an adequate oncologic operation for this tumor type.

MATERIALS AND METHODS: We analyzed the National Cancer Database to determine an optimal surgical resection for patients with a typical carcinoid tumor. We determined the number of patients who had typical carcinoid tumors. We then performed a survival analysis of the propensity-matched group of patients having a pathologic stage I typical carcinoid tumor who had undergone anatomic pulmonary resection (lobectomy and segmentectomy) or wedge resection.

RESULTS: A total of 10,265 patients met the inclusion and exclusion criteria: 8956 (87%) had a typical carcinoid tumor, while 1309 patients (13%) had an atypical carcinoid tumor. Among patients with typical carcinoid tumors, there were 7163 patients (80%) who underwent anatomic pulmonary resection (6755 patients with lobectomy, 94% and 408 patients with segmentectomy, 6%) and 1793 patients (20%) who underwent wedge resection. In this cohort, patients who had an anatomic resection had significantly improved 5-y survival compared to patients who had wedge resection (91% versus 84%, P < 0.001). In the propensity score-matched group of stage I typical carcinoid tumors (n = 1348), the patients who had an anatomic resection had significantly improved survival compared to patients who had wedge resections (89% versus 85%, P = 0.01) at 5 y.

CONCLUSIONS: The anatomic resection compared to wedge resection was associated with improved survival in patients with early-stage typical carcinoid lung cancer. Surgically fit patients should be considered for anatomic resection for typical carcinoid tumors.

Original languageEnglish (US)
Pages (from-to)352-360
Number of pages9
JournalJournal of Surgical Research
StatePublished - Jul 2022


  • Atypical carcinoid tumor
  • Lobectomy
  • Neuroendocrine tumor
  • Pulmonary resection
  • Segmentectomy
  • Survival
  • Typical carcinoid tumor
  • Wedge resection
  • Carcinoid Tumor
  • Humans
  • Carcinoma, Non-Small-Cell Lung/surgery
  • Pneumonectomy
  • Lung Neoplasms
  • Carcinoma, Neuroendocrine/pathology
  • Retrospective Studies
  • Neoplasm Staging

ASJC Scopus subject areas

  • Surgery


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