Analytical and numerical analysis of magnetic separation of cardiomyocytes

B. Cirkovic, V. Isailovic, Z. Milosevic, J. Radulovic, A. Sofla, M. Radisic, M. Kojic, N. Filipovic

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

High-gradient magnetic separation (HGMS) has attracted considerable attention in recent time, both experimentally and theoretically. It has established itself as a powerful technique for the manipulation of particles with magnetic properties. In the present study, analytical and numerical analysis of magnetic separation of cardiomyocytes (CMs) is presented. These enriched cells can be used for therapeutic or tissue engineering applications where no ?labeling? method is accepted. Calculation of applied magnetic force for these particles that can be rendered as paramagnetic inside column was performed in order to clarify the effect of magnetic field gradient on the accumulation possibility of these particles. Numerical solutions of 2D fluid-structure finite element methods are compared with semi-analytical results for combination of magnetic field strength and average flow.

Original languageEnglish (US)
Pages (from-to)145-159
Number of pages15
JournalJournal of the Serbian Society for Computational Mechanics
Volume6
Issue number2
StatePublished - 2012

Keywords

  • Cardiomyocytes
  • Finite element method
  • Hearth failure
  • Magnetic force
  • Numerical simulations
  • Paramagnetic
  • Separation

ASJC Scopus subject areas

  • Computational Mechanics

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