TY - JOUR
T1 - Analysis of the Par2 modifier of pulmonary adenoma formation in mice
AU - Wang, Min
AU - Wang, Yian
AU - You, Ming
AU - Devereux, Theodora R.
N1 - Funding Information:
Received 8 January 2004; accepted 9 February 2004. This work has been supported in part by NIH grants R01CA099147 and R01CA58554. The authors thank Cynthia Kaye for her editing of this manuscript. Address correspondence to Theodora R. Devereux, Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, National Institutes of Health, 111 Alexander Drive, Research Triangle park, NC 27709, USA. E-mail: [email protected]
PY - 2005/3
Y1 - 2005/3
N2 - Inbred strains of mice show various susceptibilities to spontaneous and chemical-induced lung tumorigenesis. Genetic analyses have revealed that lung tumor susceptibilities of inbred mouse strains are governed by quantitative trait loci (QTLs) located on multiple chromosomes. A major lung tumor resistance QTL, designated pulmonary adenoma resistance 2 (Par2), was mapped to the mouse chromosome 18 independently by several groups and accounted for up to 60% phenotype variance between the susceptible A/J and more resistant BALB/c strains. The authors recently conducted studies to positionally clone the Par2 gene. This review summarizes the effort and progress towards the identification of Par2 candidates.
AB - Inbred strains of mice show various susceptibilities to spontaneous and chemical-induced lung tumorigenesis. Genetic analyses have revealed that lung tumor susceptibilities of inbred mouse strains are governed by quantitative trait loci (QTLs) located on multiple chromosomes. A major lung tumor resistance QTL, designated pulmonary adenoma resistance 2 (Par2), was mapped to the mouse chromosome 18 independently by several groups and accounted for up to 60% phenotype variance between the susceptible A/J and more resistant BALB/c strains. The authors recently conducted studies to positionally clone the Par2 gene. This review summarizes the effort and progress towards the identification of Par2 candidates.
KW - Congenic mice
KW - DNA polymerase iota
KW - Linkage mapping
KW - Mouse lung tumor susceptibility
KW - Par2
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U2 - 10.1080/01902140490495598
DO - 10.1080/01902140490495598
M3 - Article
C2 - 15828125
AN - SCOPUS:14644431814
SN - 0190-2148
VL - 31
SP - 193
EP - 204
JO - Experimental Lung Research
JF - Experimental Lung Research
IS - 2
ER -