Analysis of the Par2 modifier of pulmonary adenoma formation in mice

Min Wang, Yian Wang, Ming You, Theodora R. Devereux

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


Inbred strains of mice show various susceptibilities to spontaneous and chemical-induced lung tumorigenesis. Genetic analyses have revealed that lung tumor susceptibilities of inbred mouse strains are governed by quantitative trait loci (QTLs) located on multiple chromosomes. A major lung tumor resistance QTL, designated pulmonary adenoma resistance 2 (Par2), was mapped to the mouse chromosome 18 independently by several groups and accounted for up to 60% phenotype variance between the susceptible A/J and more resistant BALB/c strains. The authors recently conducted studies to positionally clone the Par2 gene. This review summarizes the effort and progress towards the identification of Par2 candidates.

Original languageEnglish (US)
Pages (from-to)193-204
Number of pages12
JournalExperimental Lung Research
Issue number2
StatePublished - Mar 2005


  • Congenic mice
  • DNA polymerase iota
  • Linkage mapping
  • Mouse lung tumor susceptibility
  • Par2

ASJC Scopus subject areas

  • Molecular Biology
  • Pulmonary and Respiratory Medicine
  • Clinical Biochemistry


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