Analysis of idiotypic and anti-idiotypic antibodies as models of receptor and ligand

D. S. Linthicum, M. B. Bolger, P. H. Kussie, G. M. Albright, T. A. Linton, S. Combs, D. Marchetti

Research output: Contribution to journalReview article

14 Scopus citations

Abstract

Antibodies to small bioactive ligands and peptides may mimic the binding characteristics of the natural receptor; in turn, the anti-idiotypic antibodies generated against the binding sites of such anti-ligand antibodies may mimic some aspects of small bioactive ligands and peptides. Among the several levels of investigation of such antibody-receptor networks are (a) the quantitative structure-activity relationships of ligand binding to antibody as compared with natural receptor; (b) the molecular modeling of antibody-receptor binding sites and the genomic basis for such structures; and (c) the characteristics of the molecular mimicry exhibited by 'mimetopes' on anti-idiotypic antibodies. To illustrate the analysis encountered at each of these levels, we discuss here antibody and anti-idiotype systems that are directed to small neuroactive ligands and their receptors.

Original languageEnglish (US)
Pages (from-to)1676-1680
Number of pages5
JournalClinical Chemistry
Volume34
Issue number9
DOIs
StatePublished - 1988

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Biochemistry, medical

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