TY - JOUR
T1 - Analysis of failure in patients with adenoid cystic carcinoma of the head and neck. An international collaborative study
AU - Amit, Moran
AU - Binenbaum, Yoav
AU - Sharma, Kanika
AU - Ramer, Naomi
AU - Ramer, Ilana
AU - Agbetoba, Abib
AU - Miles, Brett
AU - Yang, Xinjie
AU - Lei, Delin
AU - Bjøerndal, Kristine
AU - Godballe, Christian
AU - Mücke, Thomas
AU - Wolff, Klaus Dietrich
AU - Fliss, Dan
AU - Eckardt, André M.
AU - Copelli, Chiara
AU - Sesenna, Enrico
AU - Palmer, Frank
AU - Patel, Snehal
AU - Gil, Ziv
PY - 2014
Y1 - 2014
N2 - Background Adenoid cystic carcinoma (ACC) is a locally aggressive tumor with a high prevalence of distant metastases. The purpose of this study was to identify independent predictors of outcome and to characterize the patterns of failure. Methods An international retrospective review was conducted of 489 patients with ACC treated between 1985 and 2011 in 9 cancer centers worldwide. Results Five-year overall-survival (OS), disease-specific survival (DSS), and disease-free survival (DFS) were 76%, 80%, and 68%, respectively. Independent predictors of OS and DSS were: age, site, N classification, and presence of distant metastases. N classification, age, and bone invasion were associated with DFS on multivariate analysis. Age, tumor site, orbital invasion, and N classification were independent predictors of distant metastases. Conclusion The clinical course of ACC is slow but persistent. Paranasal sinus origin is associated with the lowest distant metastases rate but with the poorest outcome. These prognostic estimates should be considered when tailoring treatment for patients with ACC.
AB - Background Adenoid cystic carcinoma (ACC) is a locally aggressive tumor with a high prevalence of distant metastases. The purpose of this study was to identify independent predictors of outcome and to characterize the patterns of failure. Methods An international retrospective review was conducted of 489 patients with ACC treated between 1985 and 2011 in 9 cancer centers worldwide. Results Five-year overall-survival (OS), disease-specific survival (DSS), and disease-free survival (DFS) were 76%, 80%, and 68%, respectively. Independent predictors of OS and DSS were: age, site, N classification, and presence of distant metastases. N classification, age, and bone invasion were associated with DFS on multivariate analysis. Age, tumor site, orbital invasion, and N classification were independent predictors of distant metastases. Conclusion The clinical course of ACC is slow but persistent. Paranasal sinus origin is associated with the lowest distant metastases rate but with the poorest outcome. These prognostic estimates should be considered when tailoring treatment for patients with ACC.
KW - adenoid
KW - adenoid cystic
KW - adenoid cystic carcinoma
KW - head and neck cancer
KW - salivary gland tumors
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U2 - 10.1002/hed.23405
DO - 10.1002/hed.23405
M3 - Article
C2 - 23784851
AN - SCOPUS:84902546941
VL - 36
SP - 998
EP - 1004
JO - Head and Neck Surgery
JF - Head and Neck Surgery
SN - 1043-3074
IS - 7
ER -