Analysis of failure in patients with adenoid cystic carcinoma of the head and neck. An international collaborative study

Moran Amit; Yoav Binenbaum; Kanika Sharma; Naomi Ramer; Ilana Ramer; Abib Agbetoba; Brett Miles; Xinjie Yang; Delin Lei; Kristine Bjøerndal; Christian Godballe; Thomas Mücke; Klaus Dietrich Wolff; Dan Fliss; André M. Eckardt; Chiara Copelli; Enrico Sesenna; Frank Palmer; Snehal Patel; Ziv Gil

doi:10.1002/hed.23405

Analysis of failure in patients with adenoid cystic carcinoma of the head and neck. An international collaborative study

Moran Amit, Yoav Binenbaum, Kanika Sharma, Naomi Ramer, Ilana Ramer, Abib Agbetoba, Brett Miles, Xinjie Yang, Delin Lei, Kristine Bjøerndal, Christian Godballe, Thomas Mücke, Klaus Dietrich Wolff, Dan Fliss, André M. Eckardt, Chiara Copelli, Enrico Sesenna, Frank Palmer, Snehal Patel, Ziv Gil

Houston Methodist

Research output: Contribution to journal › Article › peer-review

70 Scopus citations

Abstract

Background Adenoid cystic carcinoma (ACC) is a locally aggressive tumor with a high prevalence of distant metastases. The purpose of this study was to identify independent predictors of outcome and to characterize the patterns of failure. Methods An international retrospective review was conducted of 489 patients with ACC treated between 1985 and 2011 in 9 cancer centers worldwide. Results Five-year overall-survival (OS), disease-specific survival (DSS), and disease-free survival (DFS) were 76%, 80%, and 68%, respectively. Independent predictors of OS and DSS were: age, site, N classification, and presence of distant metastases. N classification, age, and bone invasion were associated with DFS on multivariate analysis. Age, tumor site, orbital invasion, and N classification were independent predictors of distant metastases. Conclusion The clinical course of ACC is slow but persistent. Paranasal sinus origin is associated with the lowest distant metastases rate but with the poorest outcome. These prognostic estimates should be considered when tailoring treatment for patients with ACC.

Original language	English (US)
Pages (from-to)	998-1004
Number of pages	7
Journal	Head and Neck
Volume	36
Issue number	7
DOIs	https://doi.org/10.1002/hed.23405
State	Published - 2014

Keywords

adenoid
adenoid cystic
adenoid cystic carcinoma
head and neck cancer
salivary gland tumors

ASJC Scopus subject areas

Otorhinolaryngology

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10.1002/hed.23405

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Amit, M., Binenbaum, Y., Sharma, K., Ramer, N., Ramer, I., Agbetoba, A., Miles, B., Yang, X., Lei, D., Bjøerndal, K., Godballe, C., Mücke, T., Wolff, K. D., Fliss, D., Eckardt, A. M., Copelli, C., Sesenna, E., Palmer, F., Patel, S., & Gil, Z. (2014). Analysis of failure in patients with adenoid cystic carcinoma of the head and neck. An international collaborative study. Head and Neck, 36(7), 998-1004. https://doi.org/10.1002/hed.23405

Amit, M, Binenbaum, Y, Sharma, K, Ramer, N, Ramer, I, Agbetoba, A, Miles, B, Yang, X, Lei, D, Bjøerndal, K, Godballe, C, Mücke, T, Wolff, KD, Fliss, D, Eckardt, AM, Copelli, C, Sesenna, E, Palmer, F, Patel, S & Gil, Z 2014, 'Analysis of failure in patients with adenoid cystic carcinoma of the head and neck. An international collaborative study', Head and Neck, vol. 36, no. 7, pp. 998-1004. https://doi.org/10.1002/hed.23405

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title = "Analysis of failure in patients with adenoid cystic carcinoma of the head and neck. An international collaborative study",

abstract = "Background Adenoid cystic carcinoma (ACC) is a locally aggressive tumor with a high prevalence of distant metastases. The purpose of this study was to identify independent predictors of outcome and to characterize the patterns of failure. Methods An international retrospective review was conducted of 489 patients with ACC treated between 1985 and 2011 in 9 cancer centers worldwide. Results Five-year overall-survival (OS), disease-specific survival (DSS), and disease-free survival (DFS) were 76%, 80%, and 68%, respectively. Independent predictors of OS and DSS were: age, site, N classification, and presence of distant metastases. N classification, age, and bone invasion were associated with DFS on multivariate analysis. Age, tumor site, orbital invasion, and N classification were independent predictors of distant metastases. Conclusion The clinical course of ACC is slow but persistent. Paranasal sinus origin is associated with the lowest distant metastases rate but with the poorest outcome. These prognostic estimates should be considered when tailoring treatment for patients with ACC.",

keywords = "adenoid, adenoid cystic, adenoid cystic carcinoma, head and neck cancer, salivary gland tumors",

author = "Moran Amit and Yoav Binenbaum and Kanika Sharma and Naomi Ramer and Ilana Ramer and Abib Agbetoba and Brett Miles and Xinjie Yang and Delin Lei and Kristine Bj{\o}erndal and Christian Godballe and Thomas M{\"u}cke and Wolff, {Klaus Dietrich} and Dan Fliss and Eckardt, {Andr{\'e} M.} and Chiara Copelli and Enrico Sesenna and Frank Palmer and Snehal Patel and Ziv Gil",

year = "2014",

doi = "10.1002/hed.23405",

language = "English (US)",

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pages = "998--1004",

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T1 - Analysis of failure in patients with adenoid cystic carcinoma of the head and neck. An international collaborative study

AU - Amit, Moran

AU - Binenbaum, Yoav

AU - Sharma, Kanika

AU - Ramer, Naomi

AU - Ramer, Ilana

AU - Agbetoba, Abib

AU - Miles, Brett

AU - Yang, Xinjie

AU - Lei, Delin

AU - Bjøerndal, Kristine

AU - Godballe, Christian

AU - Mücke, Thomas

AU - Wolff, Klaus Dietrich

AU - Fliss, Dan

AU - Eckardt, André M.

AU - Copelli, Chiara

AU - Sesenna, Enrico

AU - Palmer, Frank

AU - Patel, Snehal

AU - Gil, Ziv

PY - 2014

Y1 - 2014

N2 - Background Adenoid cystic carcinoma (ACC) is a locally aggressive tumor with a high prevalence of distant metastases. The purpose of this study was to identify independent predictors of outcome and to characterize the patterns of failure. Methods An international retrospective review was conducted of 489 patients with ACC treated between 1985 and 2011 in 9 cancer centers worldwide. Results Five-year overall-survival (OS), disease-specific survival (DSS), and disease-free survival (DFS) were 76%, 80%, and 68%, respectively. Independent predictors of OS and DSS were: age, site, N classification, and presence of distant metastases. N classification, age, and bone invasion were associated with DFS on multivariate analysis. Age, tumor site, orbital invasion, and N classification were independent predictors of distant metastases. Conclusion The clinical course of ACC is slow but persistent. Paranasal sinus origin is associated with the lowest distant metastases rate but with the poorest outcome. These prognostic estimates should be considered when tailoring treatment for patients with ACC.

AB - Background Adenoid cystic carcinoma (ACC) is a locally aggressive tumor with a high prevalence of distant metastases. The purpose of this study was to identify independent predictors of outcome and to characterize the patterns of failure. Methods An international retrospective review was conducted of 489 patients with ACC treated between 1985 and 2011 in 9 cancer centers worldwide. Results Five-year overall-survival (OS), disease-specific survival (DSS), and disease-free survival (DFS) were 76%, 80%, and 68%, respectively. Independent predictors of OS and DSS were: age, site, N classification, and presence of distant metastases. N classification, age, and bone invasion were associated with DFS on multivariate analysis. Age, tumor site, orbital invasion, and N classification were independent predictors of distant metastases. Conclusion The clinical course of ACC is slow but persistent. Paranasal sinus origin is associated with the lowest distant metastases rate but with the poorest outcome. These prognostic estimates should be considered when tailoring treatment for patients with ACC.

KW - adenoid

KW - adenoid cystic

KW - adenoid cystic carcinoma

KW - head and neck cancer

KW - salivary gland tumors

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Analysis of failure in patients with adenoid cystic carcinoma of the head and neck. An international collaborative study

Abstract

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