An overview of tumor necrosis factor α and the failing human heart

Guillermo Torre, Biykem Bozkurt, Anita Deswal, Douglas L. Mann

Research output: Contribution to journalReview articlepeer-review

86 Scopus citations


Recent studies have identified the importance of biologically active molecules (eg, neurohormones) in disease progression in heart failure. In addition to neurohormones, another portfolio of biologically active molecules, termed cytokines, are also expressed in the setting of heart failure. This article reviews recent clinical and experimental material that suggest that the cytokines (eg, tumor necrosis factor α), much like the neurohormones, may represent another class of biologically active molecules that are responsible for the development and progression of heart failure.

Original languageEnglish (US)
Pages (from-to)206-210
Number of pages5
JournalCurrent Opinion in Cardiology
Issue number3
StatePublished - 1999

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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